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Integrative Molecular Medicine (IMM)

Online ISSN: 2056-6360

(Editor in Chief)

Ivan Gout

University College London

Ricardo H. Alvarez

Cancer Treatment Centers of America

Integrative Molecular Medicine (IMM) is a peer-reviewed, online open access journal dedicated to a new research discipline at the interface between clinical research and basic biology. We aim to publish articles that broadly enlighten the biomedicine research community by providing an insight on breakthrough discoveries in basic and clinical medicinal research, thereby lending a strong impetus to this important and rapidly developing field and helping to forge new links between clinicians and molecular biologists. Integrative Molecular Medicine highlights ongoing integrative basic and clinical biomedicines covering fields of biology and medicine.As such the following qualities are essential in any article published by the journal: scientific credibility and rigour, and coherence and clarity in the writing. Contributions do not need to be novel as confirmatory and replication studies will be considered, however the article must present new findings, which could include the reporting of negative findings.

IMM provides a new platform for all researchers, scientists, scholars, students to publish their research work and update the latest research information.Integrative Molecular Medicine publishes research articles as full-length research papers and short reports. In addition, the journal publishes editorials and review articles in innovative formats that target a broad and non-specialized audience.

Journal will accept article from the following topics are integrative medical fields including biochemistry, molecular and cell biology, biotechnology, genetics, physiology, endocrinology, signal transduction, cell proliferation, differentiation and development, stem cells and regenerative medicine apoptosis, gene expression, pathology, metabolic disease, genomics, transcriptomics, proteomics, metabolomics of disease, systems medicine, brain disease, cardiovascular biology, diabetes, obesity, osteoporosis, nutrition, pharmacology, toxicology, cancer biology and oncology, epidemiology, genetic medicine, and other medicine-related topics.

IMM welcomes direct submissions of manuscripts from authors. You can submit your manuscript to: submissions@oatext.com; alternatively to: yamaguchi@oatext.com

Ivan Gout


I graduated as an MD at Lviv State Medical University (Ukraine) in 1983 with a great passion to become a surgeon in oncology. Thinking that a PhD in experimental oncology would help to realize my dream, I obtained my doctorate at the Institute of Experimental Oncology, National Academy of Sciences of Ukraine in 1987. A fellowship from the International Agency for Research on Cancer (IARC) took me even further from clinical oncology and also from Ukraine. I arrived in London on the first wave of perestroika and began my post-doctoral training in Jim Woodgett's laboratory at the Ludwig Institute for Cancer Research (UCL Branch). Subsequently, I worked in Mike Waterfield's laboratory at the same Institute studying signal transduction via the PI3 kinase pathway. In 1996, I started my own group at the Ludwig Institute for Cancer Research, focusing on the regulation of growth via the S6 kinase pathway. Since 2003, I have been a Professor in the Department of Biochemistry at UCL – now renamed Structural and Molecular Biology, where I have an active research group working on signal transduction and cellular metabolism in health and disease. I have a strong research (113 papers in peer-reviewed journals, H-Index 52) and patent (10 world-wide patents) portfolio and run two drug discovery programs aimed at developing small molecule inhibitors, targeting ribosomal S6 kinase and Aurora A kinase.

Ricardo H. Alvarez


Dr. Alvarez, a native of Argentina, joined CTCA in October 2014 to lead the company’s global focus on cancer research. He is internationally known for his contribution to breast cancer multidisciplinary management, inflammatory breast cancer, and discovery and monitoring of minimal residual disease in solid tumors. As a medical oncologist, he has focused his clinical career the past two decades on treating patients with the most difficult cases of breast cancer. Prior to joining CTCA, Dr. Alvarez served for five years as an Assistant Professor in the University of Texas MD Anderson Cancer Center Department of Breast Medical Oncology, Division of Cancer Medicine in Houston, Tx. He also served as Assistant Professor at The Morgan Welch Inflammatory Breast Cancer Research Program. His additional experience includes teaching at the Department of Pathology and the Department of Internal Medicine, Universidad Nacional de La Plata, Argentina. He served as Chief, Oncology Section, Hospital Ramon Carrillo - San Carlos de Bariloche, Rio Negro, Argentina, and Instructor, Oncology Consultants P.A., Houston, Tx. He was Secretary of Clinical Oncology Section, School of Oncology, Fundacion Jose Maria Mainetti, Centro Oncologico de Excelencia, Gonnet, Argentina; and Member, Centro Oncologico de Excelencia, Gonnet.

Dr. Alvarez received his medical degree from Universidad Nacional de La Plata - Facultad de Medicina, Argentina. He completed his residency in internal medicine and medical oncology at Centro Oncologico de Excelencia - Gonnet, Argentina. Following completion of his medical oncology training, he pursued additional training in Clinical Pathology to further study molecular diagnostic and serve as Instructor at the Pathology Department with Dr. Pedro Laguens at the Universidad Nacional de La Plata. He also participated in multiple research activities and attended multiple grand rounds with Professors Jose Maria Mainetti and Alberto Luchina, and with several others became leaders in Argentinean oncology. Following his training in Argentina, he moved to Houston to pursue a medical residency in internal medicine at The University of Texas at Houston, and completed a fellowship in hematology and oncology at The University of Texas MD Anderson Cancer Center, Houston, TX. He earned a master’s degree in cancer biology from the Graduate School of Biomedical Sciences at Houston. Dr. Alvarez has received numerous professional awards for his work in cancer research, including T-32 NIH CA009666 in 2006, Award of Excellence in Cancer Research by Texas Medical Society of Oncology in 2008, and the Susan Papizan Dolan Fellowship in Breast Cancer Research in 2008. He has participated in nearly $5 million in research grants and contracts with multiple clinical studies, including several Phase II Investigator Initiated Studies, since 2009 alone.

In 2014, he was Principal Investigator in a study related to monitoring minimal residual disease in locally advanced breast cancer and inflammatory breast cancer by detecting circulating tumor cells. The goal of this study, funded by Sister Institution Fund Network as part of the Global Academy Program Department at MD Anderson, is to identify molecular markers of breast cancer tumor recurrence. This clinical trial is currently active in the U.S., as well as in five academic Institutions across the world, including: INCan in Mexico, INEM in Peru, ClÍnica Alemana in Santiago de Chile, Barretos Hosptial in Brasil, and University of Oslo in Norway. Dr. Alvarez has authored more than 50 articles, abstracts and book chapters and is a frequent presenter at international oncology conferences. His professional memberships include: American Society of Clinical Oncology (ASCO,) American College of Physicians (ACP), American Society of Hematology (ASH), American Association of Cancer Research (AACR), and the Society of Clinical Research Associates (SOCRA). He was a founding member of Grupo de Estudio Tratamiento e Investigacion del Cancer del Sur (GETICS) in Argentina in 1996.

Regional Editor-in-Chief


Hans-Peter Deigner (Europe)

Dean, Faculty of Medical & Life Sciences
Professor of Pharmacology
Furtwangen University
Germany

Susumu Minamisawa (Asia Pacific)

Professor
Department of Cell Physiology
The Jikei University School of Medicine Japan

Arnon Blum (Middle East)

Professor of Medicine
Faculty of Medicine
Bar Ilan University
Israel

Editorial Board


George Perry

Professor and Dean of College of Sciences
University of Texas at San Antonio

Anupam Bishayee

Associate Professor & Chair
Department of Pharmaceutical Sciences
School of Pharmacy
American University of Health Sciences

Ali Cyrus Banan

Professor of Medicine & Physiology
Executive Director of Translational Medicine Research University of South Carolina School of Medicine


Rafat A. Siddiqui

Senior Investigator/Director
Cellular Biochemistry Laboratory
Methodist Research Institute
Indiana University Health
Adjunct Professor of Medicine
Department of Medicine
Indiana University School of Medicine

Jennifer Li

Assistant Professor of Histology
Department of Biomedical Sciences
Mercer University School of Medicine

Bruno Sobral

Adjunct Professor
Virginia Bioinformatics Institute at Virginia Tech
Adjunct Professor, Department of Cancer Biology
Wake Forest School of Medicine


Cheng-Jeng Tai

Director/Associate Professor
Division of Hematology and Oncology
Taipei Medical Univesity Hospital

David W. Moskowitz

CEO & Chief Medical Officer
GenoMed, Inc.
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Sotirios G. Stergiopoulos

Executive Director US Medical Affairs Oncology,
Breast Disease Lead Celgene


Basel al-Ramadi

Professor and Chair
Department of Medical Microbiology & Immunology
College of Medicine and Health Sciences
United Arab Emirates University

Mawieh Hamad

Associate Professor
Department of Medical Laboratory Sciences
University of Sharjah

Zoran M Pavlovic

Medical Director CNS
PRA International, Germany


Khalid Siddiqui

Head Biochemistry & Molecular Genetics Lab,
Strategic Center for Diabates Research
King Saud University

Russell Weiner

Executive Director & Head
Merck Clinical Biomarker and Diagnostics Lab

Shahid Siddiqui

Professor of Genetics, Director
Program in Human Genetics & Development
Head, Research Strategy Unit
Faculty of Dentistry and Medicine
Umm-Al-Qura University


Mohamed A. Sabry

Associate Professor
Department of Medical Biochemistry
College of Medicine & Medical Sciences
Arabian Gulf University

Glen J. Weiss

Clinical Associate Professor
Translational Genomics Research Institute (TGen)
Clinical Assistant Professor of Medicine
The University of Arizona College of Medicine-Phoenix
Director of Clinical Research
Cancer Treatment Centers of America

Lilach Soreq

Marie Curie Research Associate
Department of Molecular Neuroscience
UCL Institute of Neurology
United Kingdom


Derek A. Wainwright

Assistant Professor
Department of Neurological Surgery
Northwestern University
Feinberg School of Medicine

Kulvinder Singh Saini

Senior Consultant
Professor of Biotechnology and Genomics
King Abdulaziz University

Tosson Alymorsy

Professor of Parasitology
Faculty of Medicine
Ain Shams University


Tomiyasu Murata

Associate Professor
Departments of Analytical Neurobiology
Faculty of Pharmacy
Meijo University

Vural Fidan

Deputy Director of Otorhinolaryngology Department
Yunus Emre Government Hospital

Faris Q. Alenzi

Professor of Immunology
College of Applied Medical Sciences
Salman bin Abdulaziz University


Ahmed Malki

Associate Professor
Coordinator of Biomedical Science Graduate Program
Department of Health Sciences
College of Arts and Sciences
Qatar University

Omar Bagasra

Professor, Department of Biology
Director
South Carolina Center for Biotechnology
Claflin University

Renee Dufault

Founding Director
Food Ingredient and Health Research Institute


Asim Ahmed Elnour

Adjunct Clinical Associate Professor
Pharmacology Department
Faculty of Medicine and Health Sciences (FMHS)
United Arab Emirates University (UAEU)

Pinar Erkekoglu

Associate Professor of Toxicology
Faculty of Pharmacy
Department of Toxicology
Hacettepe University

Zhongjie Ma

Senior Research Scientist
Boston Biomedical Inc.,
Preclinical and Drug Development


Satoru Osuka

Department of Neurosurgery
Winship Cancer Institute
Emory University

Tadaaki Miyazaki

Professor
Department of Probiotics Immunology
Institute for Genetic Medicine
Hokkaido University

William CS Cho

Department of Clinical Oncology

Queen Elizabeth Hospital, Hong Kong


Bin Yang

Associate Professor and Staff Pathologist
Director of Molecular Cytopathology
Director of International Business Development
Pathology & Laboratory Medicine Institute
Cleveland Clinic Lerner College of Medicine

Jon Ver Halen

Associate Professor
Department of Plastic Surgery
Texas A&M School of Medicine

Marco Weiergräber (MD,PhD)

Specialist in Physiology, Director and Professor
Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM))
53175 Bonn, Germany


Ali Gholamrezanezhad, MD, ABR, FEBNM

Department of Radiology
University Hospitals of Cleveland
Case Western Reserve University
Cleveland, Ohio, USA

Andrea Ottonello

Adjunct Professor
Department of Surgical and Diagnostic Integrated Sciences
University of Genoa, Italy

Early View

Volume 3, Issue 6


Is Emilin-1 a molecular link contributing to the extension of thoracic aortic aneurysm dissection and increasing the magnitude of the associated hypertension

Simon W Rabkin

Short Communication-Integrative Molecular Medicine (IMM)

November 18, 2016


Computational tools and interdisciplinary ingenuity for accelerating the development of new medicine

Matthew E. Welsch Sotirios G. Stergiopoulos

Short Communication-Integrative Molecular Medicine (IMM)

November 21, 2016


Aggregation of Sphingosine-DNA and cell construction using components from egg white

Shoshi Inooka

Research Article-Integrative Molecular Medicine (IMM)

November 24, 2016


Current Issue

Volume 3, Issue 5


Effect of 3-hydroxybutyrate, an endogenous histone deacetylase inhibitor, on FOXO3A mRNA expression in human epithelial colorectal Caco-2 cells: Insight into the epigenetic mechanisms of electric field therapy

Yuzo Nakagawa-Yagi Hiroyuki Hara Hidenori Tsuboi Junji Abe Akikuni Hara

Research Article-Integrative Molecular Medicine (IMM)

September 13, 2016


New scaffolds of inhibitors targeting the DNA binding of NF-κB

Takanobu Kobayashi Sei-ich Tanuma Katsuhito Kino Hiroshi Miyazawa

Research Article-Integrative Molecular Medicine (IMM)

September 19, 2016


Hb Crete in a Turkish Family with Crete Island origin

Duran Canatan İbrahim Keser Türker Bilgen Serpil Delibaş

Short Communication-Integrative Molecular Medicine (IMM)

September 26, 2016


Hypothalamus-pituitary-adrenal (HPA) axis, chronic stress, hair cortisol, metabolic syndrome and mindfulness

Helen Patricia Gaete

Short Communication-Integrative Molecular Medicine (IMM)

October 05, 2016


Metabolic comfort in oncology and free amino acids: perspectives for the use of their regulatory actions in physiological concentrations

Karavay A Karavay P Kaliada T Nefyodov L

Short Communication-Integrative Molecular Medicine (IMM)

October 17, 2016


The effect of trans-resveratrol on the expression of the human DNA-repair associated genes

Fumiaki Uchiumi Jun Arakawa Yutaka Takihara Motohiro Akui Sayaka Ishibashi Sei-ichi Tanuma

Review article-Integrative Molecular Medicine (IMM)

October 20, 2016


Ruptured intracranial dermoid cyst: a case report

Domenico Murrone Bruno Romanelli Aldo Ierardi

Case Report-Integrative Molecular Medicine (IMM)

October 19, 2016


Characterization of small leucine-rich proteoglycans in aortic valves of patients with aortic valve stenosis

Hiroshi Furukawa Masahide Chikada Michiyo K. Yokoyama Mitsumi Arito Manae S. Kurokawa Toshiyuki Sato
Masaaki Sato Kazuki Omoteyama Naoya Suematsu Toshiya Kobayashi Masahiro Sagane Hirotoshi Suzuki Takashi Ando
Tomohiro Kato Tsuyoshi Miyairi

Research Article-Integrative Molecular Medicine (IMM)

October 28, 2016


Exercise, interleukins and bone homeostasis

John Kelly Smith

Short Communication-Integrative Molecular Medicine (IMM)

October 28, 2016


The benefits of incorporating basic sciences and translational research into a pharmacy school curriculum

Rachel R. Miller Gregory S. Gorman

Editorial-Integrative Molecular Medicine (IMM)

October 29, 2016


The Re-Emerging Role of Iron in Infection and Immunity

Mawieh Hamad Khuloud Bajbouj

Commentary Article-Integrative Molecular Medicine (IMM)

October 29, 2016


Investigation of Mutations in Exon 7,8 and Exon 9 of FHIT Gene in Laryngeal Squamous Cell Carcinoma

Nesrin Turaçlar Hasibe Cingilli Vural Şahande Elagöz Emine Elif Altuntaş Fikriye Polat

Research Article-Integrative Molecular Medicine (IMM)

October 31, 2016


Previous Issue

Volume 3, Issue 4


Repetitive stretching enhances the formation of neurite swellings in cultured neuronal cells

Hiromichi Nakadate Evrim Kurtoglu Shota Shirasaki Shigeru Aomura

Research Article-Integrative Molecular Medicine (IMM)

August 06, 2016


Anticholinergic activity disappears soon after the prescription of cholinesterase inhibitor

Taishi Koganemaru Koji Hori Misa Hosoi Kimiko Konishi Mitsugu Hachisu Hiroi Tomioka Masayuki Tani Yuka Kitajima Atsuko Inamoto

Case Report-Integrative Molecular Medicine (IMM)

August 09, 2016


Proteomics and molecular medicine

Margaret Simonian

Editorial-Integrative Molecular Medicine (IMM)

August 09, 2016


Distinguishing malignant from benign prostate using Br, Ca, K, Mg, Mn, and Na content in prostatic tissue

Vladimir Zaichick Sofia Zaichick

Research Article-Integrative Molecular Medicine (IMM)

August 10, 2016


DNA microarray analysis of gene expression changes in ICR mouse liver following treatment with active hexose correlated compound

Koji Wakame Akifumi Nakata Keisuke Sato Takehito Miura Anil.D.Kulkarni Marie-Francoise Doursout Alamelu Sundersan Ken-Ich Komatsu

Research Article-Integrative Molecular Medicine (IMM)

August 10, 2016


A bright future for breast and colon cancer patients

Veronica J. James Mark McGovern Peihong Wu Boyang Chang Yankeng Wu

Mini Review-Integrative Molecular Medicine (IMM)

August 18, 2016


Cancer incidence and the biology of extreme old age

Josh Hiller Celeste Vallejo Leo Betthauser James Keesling

Research Article-Integrative Molecular Medicine (IMM)

August 19, 2016


Distinct functional roles of cancerous immunoglobulins in cancer immunology

Gregory Lee

Research Article-Integrative Molecular Medicine (IMM)

August 25, 2016


Antitumor activities of BIBF 1120, BI 860585, and BI 836845 in preclinical models of sarcoma

Yoko Takai Asuka Matsuo Zhiwei Qiao Tadashi Kondo

Research Article-Integrative Molecular Medicine (IMM)

August 26, 2016


Kynurenic acid, an aryl hydrocarbon receptor ligand, is elevated in serum of Zucker fatty rats

Oxenkrug G Cornicelli J van der Hart M Roeser J Summergrad P

Research Article-Integrative Molecular Medicine (IMM)

August 29, 2016


Regulatory role of heat-shock proteins in autoimmune and inflammatory diseases

Cristina Daneri-Becerra Mario D. Galigniana

Research Article-Integrative Molecular Medicine (IMM)

August 22, 2016


Immunotherapy in basal cell carcinoma

Nepton Sheik Khoni GhazalehShoja E Razavi Himakshi Sharma

Research Article-Integrative Molecular Medicine (IMM)

August 22, 2016


Suppressor of cytokine signaling and rheumatoid arthritis

Charles J. Malemud

Research Article-Integrative Molecular Medicine (IMM)

September 05, 2016


Immunotherapy for cancers of the biliary tract

Nepton Sheik Khoni Abdul Rahman El Kinge Abdul Rahman El Kinge

Perspective-Integrative Molecular Medicine (IMM)

August 30, 2016


Archive


Volume 3

Effect of 3-hydroxybutyrate, an endogenous histone deacetylase inhibitor, on FOXO3A mRNA expression in human epithelial colorectal Caco-2 cells: Insight into the epigenetic mechanisms of electric field therapy

Yuzo Nakagawa-Yagi Hiroyuki Hara Hidenori Tsuboi Junji Abe Akikuni Hara

Research Article-Integrative Molecular Medicine (IMM)

September 13, 2016


New scaffolds of inhibitors targeting the DNA binding of NF-κB

Takanobu Kobayashi Sei-ich Tanuma Katsuhito Kino Hiroshi Miyazawa

Research Article-Integrative Molecular Medicine (IMM)

September 19, 2016


Hb Crete in a Turkish Family with Crete Island origin

Duran Canatan İbrahim Keser Türker Bilgen Serpil Delibaş

Short Communication-Integrative Molecular Medicine (IMM)

September 26, 2016


Hypothalamus-pituitary-adrenal (HPA) axis, chronic stress, hair cortisol, metabolic syndrome and mindfulness

Helen Patricia Gaete

Short Communication-Integrative Molecular Medicine (IMM)

October 05, 2016


Metabolic comfort in oncology and free amino acids: perspectives for the use of their regulatory actions in physiological concentrations

Karavay A Karavay P Kaliada T Nefyodov L

Short Communication-Integrative Molecular Medicine (IMM)

October 17, 2016


The effect of trans-resveratrol on the expression of the human DNA-repair associated genes

Fumiaki Uchiumi Jun Arakawa Yutaka Takihara Motohiro Akui Sayaka Ishibashi Sei-ichi Tanuma

Review article-Integrative Molecular Medicine (IMM)

October 20, 2016


Ruptured intracranial dermoid cyst: a case report

Domenico Murrone Bruno Romanelli Aldo Ierardi

Case Report-Integrative Molecular Medicine (IMM)

October 19, 2016


Characterization of small leucine-rich proteoglycans in aortic valves of patients with aortic valve stenosis

Hiroshi Furukawa Masahide Chikada Michiyo K. Yokoyama Mitsumi Arito Manae S. Kurokawa Toshiyuki Sato
Masaaki Sato Kazuki Omoteyama Naoya Suematsu Toshiya Kobayashi Masahiro Sagane Hirotoshi Suzuki Takashi Ando
Tomohiro Kato Tsuyoshi Miyairi

Research Article-Integrative Molecular Medicine (IMM)

October 28, 2016


Exercise, interleukins and bone homeostasis

John Kelly Smith

Short Communication-Integrative Molecular Medicine (IMM)

October 28, 2016


The benefits of incorporating basic sciences and translational research into a pharmacy school curriculum

Rachel R. Miller Gregory S. Gorman

Editorial-Integrative Molecular Medicine (IMM)

October 29, 2016


The Re-Emerging Role of Iron in Infection and Immunity

Mawieh Hamad Khuloud Bajbouj

Commentary Article-Integrative Molecular Medicine (IMM)

October 29, 2016


Investigation of Mutations in Exon 7,8 and Exon 9 of FHIT Gene in Laryngeal Squamous Cell Carcinoma

Nesrin Turaçlar Hasibe Cingilli Vural Şahande Elagöz Emine Elif Altuntaş Fikriye Polat

Research Article-Integrative Molecular Medicine (IMM)

October 31, 2016


Repetitive stretching enhances the formation of neurite swellings in cultured neuronal cells

Hiromichi Nakadate Evrim Kurtoglu Shota Shirasaki Shigeru Aomura

Research Article-Integrative Molecular Medicine (IMM)

August 06, 2016


Anticholinergic activity disappears soon after the prescription of cholinesterase inhibitor

Taishi Koganemaru Koji Hori Misa Hosoi Kimiko Konishi Mitsugu Hachisu Hiroi Tomioka Masayuki Tani Yuka Kitajima Atsuko Inamoto

Case Report-Integrative Molecular Medicine (IMM)

August 09, 2016


Proteomics and molecular medicine

Margaret Simonian

Editorial-Integrative Molecular Medicine (IMM)

August 09, 2016


Distinguishing malignant from benign prostate using Br, Ca, K, Mg, Mn, and Na content in prostatic tissue

Vladimir Zaichick Sofia Zaichick

Research Article-Integrative Molecular Medicine (IMM)

August 10, 2016


DNA microarray analysis of gene expression changes in ICR mouse liver following treatment with active hexose correlated compound

Koji Wakame Akifumi Nakata Keisuke Sato Takehito Miura Anil.D.Kulkarni Marie-Francoise Doursout Alamelu Sundersan Ken-Ich Komatsu

Research Article-Integrative Molecular Medicine (IMM)

August 10, 2016


A bright future for breast and colon cancer patients

Veronica J. James Mark McGovern Peihong Wu Boyang Chang Yankeng Wu

Mini Review-Integrative Molecular Medicine (IMM)

August 18, 2016


Cancer incidence and the biology of extreme old age

Josh Hiller Celeste Vallejo Leo Betthauser James Keesling

Research Article-Integrative Molecular Medicine (IMM)

August 19, 2016


Distinct functional roles of cancerous immunoglobulins in cancer immunology

Gregory Lee

Research Article-Integrative Molecular Medicine (IMM)

August 25, 2016


Antitumor activities of BIBF 1120, BI 860585, and BI 836845 in preclinical models of sarcoma

Yoko Takai Asuka Matsuo Zhiwei Qiao Tadashi Kondo

Research Article-Integrative Molecular Medicine (IMM)

August 26, 2016


Kynurenic acid, an aryl hydrocarbon receptor ligand, is elevated in serum of Zucker fatty rats

Oxenkrug G Cornicelli J van der Hart M Roeser J Summergrad P

Research Article-Integrative Molecular Medicine (IMM)

August 29, 2016


Regulatory role of heat-shock proteins in autoimmune and inflammatory diseases

Cristina Daneri-Becerra Mario D. Galigniana

Research Article-Integrative Molecular Medicine (IMM)

August 22, 2016


Immunotherapy in basal cell carcinoma

Nepton Sheik Khoni GhazalehShoja E Razavi Himakshi Sharma

Research Article-Integrative Molecular Medicine (IMM)

August 22, 2016


Suppressor of cytokine signaling and rheumatoid arthritis

Charles J. Malemud

Research Article-Integrative Molecular Medicine (IMM)

September 05, 2016


Immunotherapy for cancers of the biliary tract

Nepton Sheik Khoni Abdul Rahman El Kinge Abdul Rahman El Kinge

Perspective-Integrative Molecular Medicine (IMM)

August 30, 2016


Clinical potential of DAC-70 sol

Akio Sugitachi Naoko Takahashi Yoshimori Takamori

Research Article-Integrative Molecular Medicine (IMM)

May 12, 2016


Characterization of osteoarthritis in patients with diabetes mellitus type 2

Alexander P Lykov Elena P Trifonova Olga V Sazonova Elena V Zonova

Research Article-Integrative Molecular Medicine (IMM)

May 14, 2016


Stretch-induced functional disorder of axonal transport in the cultured rat cortex neuron

Shigeru Aomura Hiromichi Nakadate Yuma Kaneko Akiyoshi Nishimura Remy Willinger

Research Article-Integrative Molecular Medicine (IMM)

May 18, 2016


Effects of soy peptides on IL-1β-induced matrix-degrading enzymes in human articular chondrocytes

Mitsumi Arito Hiroyuki Mitsui Manae S Kurokawa Kazuo Yudoh Toshikazu Kamada Hisateru Niki Tomohiro Kato

Research Article-Integrative Molecular Medicine (IMM)

May 26, 2016


Cadherin/catenin signaling in developmental biology and pathology

Zen Kouchi

Research Article-Integrative Molecular Medicine (IMM)

May 27, 2016


The canonical Wnt signal paradoxically regulates osteoarthritis development through the endochondral ossification process

Hiroshi Kawaguchi

Short Communication-Integrative Molecular Medicine (IMM)

May 27, 2016


Induction of the expression of GABARAPL1 by hydrogen peroxide in C6 glioma cells

Yoshimitsu Kiriyama Kunihiko Kasai Katsuhito Kino Hiromi Nochi

Research Article-Integrative Cancer Science and Therapeutics (ICST)

June 10, 2016


Induction of the expression of GABARAPL1 by hydrogen peroxide in C6 glioma cells

Yoshimitsu Kiriyama Kunihiko Kasai Katsuhito Kino Hiromi Nochi

Research Article-Integrative Cancer Science and Therapeutics (ICST)

June 10, 2016


Anti-aging effects of Lactobacilli

Hisako Nakagawa Tadaaki Miyazaki

Review Article-Integrative Cancer Science and Therapeutics (ICST)

June 13, 2016


Intranasal insulin administration does not modulate incretin secretion, gastric emptying, and appetite in healthy young adults

Yoshikazu Hirasawa Hisayo Yokoyama Nooshin Naghavi Yoshihiro Yamashina Ryosuke Takeda Akemi Ota Daiki Imai Tomoaki Morioka Masanori Emoto Kazunobu Okazaki

Research Article-Integrative Molecular Medicine (IMM)

June 17, 2016


Nrf2 gene as a double-edged sword: Clinical relevance of its genetic polymorphisms

Toshihisa Ishikawa Masaharu Shinkai Takeshi Kaneko

Mini Review-Integrative Molecular Medicine (IMM)

June 22, 2016


Acute appendicitis revisited: computed tomography and ultrasound scan are they necessary to establish a diagnosis?

Osman A Hamour Eman M.Fallatah Rawan O. Alshehri Zain A. Alshareef Halah F.AL-Enizi

Research Article-Integrative Molecular Medicine (IMM)

June 23, 2016


Primary cilia-mediated intercellular signaling in hair follicles

Kazuyuki Matsushima Mika Suematsu Chie Mifude Kuniyoshi Kaseda

Research Article-Integrative Molecular Medicine (IMM)

June 24, 2016


Trophic factors intervention regenerates the nestin-expressing cell population in a model of perinatal excitotoxicity: Implications for perinatal brain injury and prematurity

A. Espinosa-Jeffrey R. A. Arrazola B. Chu A. Taniguchi S. M. Barajas P. Bokhoor J. Garcia A. Feria-Velasco J. de Vellis

Research Article-Integrative Molecular Medicine (IMM)

June 25, 2016


The influence of a passion flower extract on free testosterone in healthy men: a two part investigation involving younger and older men

Richard J. Bloomer John J. MacDonnchadh Trint A. Gunnels John Henry M. Schriefer

Research Article-Integrative Molecular Medicine (IMM)

February 16, 2016


Different associations of premorbid intelligence vs. current cognition with BMI, insulin and diabetes in the homebound elderly

Mkaya Mwamburi Wei Qiao Qiu

Research Article-Integrative Molecular Medicine (IMM)

February 19, 2016


Comparative effect of ultrasound therapy with conventional therapy on breast engorgement in immediate post-partum mothers: A randomized controlled trial

Powar Priyanka Basavaraj C Ramannavar A Geeta Kurhade Arvind Kurhade Angel Justiz-Vaillant Rajarm Powar Sehlule Vuma

Research Article-Integrative Molecular Medicine (IMM)

March 02, 2016


Surgical resection and long-term disease-free survival in stage IIIB non-small cell lung cancer after gefitinib down-staging: a case report

Natella Jafarova Gary Dewar R Petter Tonseth David L. Saltman

Research Article-Integrative Molecular Medicine (IMM)

March 08, 2016


Important high light on diabetes in acute coronary syndrome cases: Saudi Arabia

Khalid A. AlNemer

Research Article-Integrative Molecular Medicine (IMM)

March 09, 2016


Adipose-derived adult stem cells and new technique for intracavernosal injection for erectile dysfunction: novel approach to treat diabetes mellitus. Erectus Shot Technique

Carlos Mercado,MD

Review Article-Integrative Molecular Medicine (IMM)

March 11, 2016


Blockade of the neuropeptide Y Y2 receptor with the potent antagonist BIIE0246 regulates gene expression levels in the lipid metabolic pathways in human hepatoma cell line HepG2

Kaji H Okada M Hamaue A Mori M Nagai M

Research Article-Integrative Molecular Medicine (IMM)

March 16, 2016


Gestational-diabetes-in-New-Zealand-ethnic-groups

Ljiljana M Jowitt

Review Article-Integrative Molecular Medicine (IMM)

March 21, 2016


Hypothalamic mitochondria in energy homeostasis and obesity

Xin Guo Lei Wu Weiqun Wang Denis M Medeiros Stephen Clarke Edralin Lucas Brenda Smith Winyoo Chowanadisai Winyoo Chowanadisai Dingbo Lin

Review Article-Integrative Molecular Medicine (IMM)

March 24, 2016


Acute exposure to an electric field induces changes in human plasma 9-HODE, 13-HODE, and immunoreactive substance P levels: Insight into the molecular mechanisms of electric field therapy

Yuzo Nakagawa-Yagi Hiroyuki Hara Fumiyuki Nakagawa Masashi Sato Akikuni Hara

Research Article-Integrative Molecular Medicine (IMM)

March 31, 2016


Incidence of gastric carcinoma at King Faisal Specialist Hospital- Jeddah Saudi Arabia: a hospital-based study

Raha Alahmadi Osman Hamour Al-Enizi H Tashkandi A

Research Article-Integrative Molecular Medicine (IMM)

April 01, 2016


Diabetes and periodontitis: multidisciplinary management

Harinder S. Sandhu Jaffer A

Research Article-Integrative Molecular Medicine (IMM)

April 05, 2016


Growth hormone releasing peptide-6 (GHRP-6) and other related secretagogue synthetic peptides: A mine of medical potentialities for unmet medical needs

Jorge Berlanga-Acosta Gerardo Guillen Nieto Ernesto Lopez-Mola Luis Herrera-Martinez

Review Article-Integrative Molecular Medicine (IMM)

April 15, 2016


Single subanesthesia dose of ketamine enhances GluR1 Ser845 phosphorylation in prefrontal cortex

Mingfa Huang Ke Zhang Xiang Cai

Research Article-Integrative Molecular Medicine (IMM)

April 19, 2016


Enhancement of physical fitness by black ginger extract rich in polymethoxyflavones: a double-blind randomized crossover trial

Kazuya Toda Marina Kohatsu Shogo Takeda Norihito Shimizu Hiroshi Shimoda

Research Article-Integrative Molecular Medicine (IMM)

April 23, 2016


Interferon response and virus-host interaction in aspect of microRNAs regulation

Thananya Jinato Kritsada Khongnomnan Emily Johnson Witthaya Poomipak Jarika Makkoch Sunchai Payungporn

Review Article-Integrative Molecular Medicine (IMM)

December 03, 2015


The effects of herbal teas on drug permeability

Akira Nakatsuma Satoshi Wada Junji Kamano Yoshimitsu Kiriyama Katsuhito Kino Masaki Ninomiya

Research Article-Integrative Molecular Medicine (IMM)

December 07, 2015


Pharmacological regulation of bladder cancer by miR-130 family seed-targeting LNA

Hiroshi Egawa Kentaro Jingushi Takayuki Hirono Ryo Hirose Yoshino Nakatsuji Yuko Ueda Kaori Kitae Kazutake Tsujikawa

Research Article-Integrative Molecular Medicine (IMM)

December 08, 2015


For the comments on DNA replication, telomere function and cancer action

Adnan Y. Rojeab

Commentary-Integrative Molecular Medicine (IMM)

December 11, 2015


Diabetes drugs that protect pancreatic β cells

Akira Nakatsuma Yoshimitsu Kiriyama Katsuhito Kino Masaki Ninomiya

Review Article -Integrative Molecular Medicine (IMM)

December 12, 2015


The effect of mild electrical stimulation with heat shock on diabetic KKAy mice

Yukari Kai Yu Tsurekawa Ryosuke Fukuda Kohei Omachi Mariam Piruzyan Yuka Okamoto Keishi Motomura Mary Ann Suico Tsuyoshi Shuto Tatsuya Kondo Eiichi Araki Hirofumi Kai

Research Article-Integrative Molecular Medicine (IMM)

December 17, 2015


Effect of fasting and refeeding on the consequences of myocardial infarction in rats

Alcione Lescano de Souza Junior Christiane Malfitano Diego Figueroa Leandro Eziquiel de Souza Eliane Ignotti Maria Cláudia Irigoyen Rui Curi

Research Article-Integrative Molecular Medicine (IMM)

December 28, 2015


Pathogenesis of idiopathic nephrotic syndrome in children: molecular mechanisms and therapeutic implications

Samuel N Uwaezuoke

Mini Review-Integrative Molecular Medicine (IMM)

December 28, 2015


Cav2.2-mediated signaling in the neural circuits underlying anxiety

Ying Zhou Kimie Niimi Weidong Li Eiki Takahashi

Research Article-Integrative Molecular Medicine (IMM)

December 28, 2015


Mechanical triggering of Wnt3a and beta-catenin in 3D bioreactors: The role of frequency and rhythm

Máximo-Alberto Díez-Ulloa Ramiro Couceiro-Otero

Research Article-Integrative Molecular Medicine (IMM)

January 07, 2016


A new strategy for mitigation of the allergenic activity of ovomucoid in hen eggs and beta-lactoglobulin in cow milk

Jun Kido Natsuko Nishi Sachiko Misumi Tomoaki Matsumoto

Review Article-Integrative Molecular Medicine (IMM)

January 25, 2016


Significance of β-Crosslaps and the tumour markers in diseases of the prostate gland

Lukas J. Becker Gerhard M. Oremek

Research Article-Integrative Molecular Medicine (IMM)

February 28, 2016


The protection effects of different dosages of ulinastatin on myocardial

Yanbo Ling Jianxin Sun

Short Communication -Integrative Molecular Medicine (IMM)

February 5, 2016


Distribution of plexin and neuropilin mRNAs in the cranium and brain stem of chick embryos

Ziaul Haque Qin Pu Ruijin Huang

Research Article-Integrative Molecular Medicine (IMM)

February 15, 2016


Angiotensin II type I receptor blocker, Losartan, inhibits fibrosis in liver by suppressing TGF-beta1 production

Hisanobu Ogata Hideko Noguchi Toshio Ohtsubo Jiyuan Liao Hiroshi Kohara Kazunari Yamada Mutsunori Murahashi Yasuki Hijikata Atsushi Suetsugu Robert M Hoffman Kenzaburo Tani

Research Article-Integrative Molecular Medicine (IMM)

February 15, 2016


A quantum theory of disease, including cancer and aging

Jerry I. Jacobson

Research Article-Integrative Molecular Medicine (IMM)

February 15, 2016


Volume 2

Inhibition of Cav2.2-mediated signaling disrupts conditioned fear extinction

Ying Zhou Kimie Niimi Weidong Li Eiki Takahashi

Research Article-Integrative Molecular Medicine (IMM)

January 07, 2015


Effect of 24,25-dihydroxyvitamin D3 on localization of catalase in chick enterocytes

Yang Zhang Ilka Nemere

Research Article-Integrative Molecular Medicine (IMM)

January 09, 2015


Lack of association between CGRP-related gene polymorphisms and medication overuse headache in migraine patients

Masakazu Ishii Hirotaka Katoh Tatsuya Kurihara Ken-ichi Saguchi Shunichi Shimizu Mitsuru Kawamura

Research Article-Integrative Molecular Medicine (IMM)

January 14, 2015


Effects of Cav2.2 inhibitor on hippocampal spatial short-term cognition

Ying Zhou Kimie Niimi Weidong Li Eiki Takahashi

Research Article-Integrative Molecular Medicine (IMM)

January 19, 2015


Flavonoid glucuronides isolated from spinach inhibit IgE-mediated degranulation in basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice

Yuta Morishita Emi Saito Eri Takemura Ryoma Fujikawa Ryohei Yamamoto Masanori Kuroyanagi Osamu Shirota Norio Muto

Research Article-Integrative Molecular Medicine (IMM)

January 27, 2015


The nutritional status of women of the coastal region of the Great East Japan Earthquake disaster area: Three years after

Yuka Kotozaki

Short Report-Integrative Molecular Medicine (IMM)

February 02, 2015


Disruption of spatial cognition by intra-accumbens injection of Cav2.2 inhibitor

Ying Zhou Kimie Niimi Weidong Li Eiki Takahashi

Research Article-Integrative Molecular Medicine (IMM)

February 07, 2015

Review of genomics of Barrett’s esophagus and esophageal adenocarcinoma

Khaled Assim Karkout Amgad El Sherif Mohammed Yaman Dongfeng Tan Sadir Al Rawi

Mini Review-Integrative Molecular Medicine (IMM)

February 18, 2015


A fine structure study on osteogenesis of mesenchymal stem cells cultured with a 3D collagen scaffold

Shunji Kumabe Michiko Nakatsuka Rie Iwai Katsura Ueda Yoshifumi Matsuda Shosuke Morita Yasutomo Iwai

Research Article-Integrative Molecular Medicine (IMM)

March 05, 2015


Mental health as a clinical hallmark of cancer

Manuela Malaguti-Boyle

Review Article-Integrative Molecular Medicine (IMM)

March 12, 2015


Prognostic significance of insulin-like growth factor-II mRNA-binding protein 3 in urological cancers: a systemic review and meta-analysis

Da-wei Sun Ying-yi Zhang Yue Qi Yu-guo Chen Jian Ma Gui-qi Liu Guo-yue Lv

Research Article-Integrative Molecular Medicine (IMM)

March 16, 2015


Cav2.2-mediated NMDA receptor signaling in short-term memory

Ying Zhou Kimie Niimi Weidong Li Eiki Takahashi

Research Article-Integrative Molecular Medicine (IMM)

March 16, 2015


Marine algae Sargassum horneri bioactive factor suppresses proliferation and stimulates apoptotic cell death in human breast cancer MDA-MB-231 cells in vitro

Masayoshi Yamaguchi Toru Matsumoto

Research Article-Integrative Molecular Medicine (IMM)

March 17, 2015


Synergy between depression and Alzheimer’s disease: A spectrum model of genomic vulnerability with therapeutic implications

Roberto Rodrigues Farhan Ahmad George Perry Robert Petersen

Research Article-Integrative Molecular Medicine (IMM)

March 17, 2015


Association analysis of CYP2A6 polymorphism to sudden and unexpected death of infants

Motoki Osawa Yoshihiko Inaoka Masato Nakatome Keiko Miyashita Eriko Ochiai Yu Kakimoto Fumiko Satoh Ryoji Matoba

Research Article-Integrative Molecular Medicine (IMM)

March 23, 2015


Non-invasive scoring systems for predicting NASH in Japan: evidences from Japan Study Group of NAFLD

Yoshio Sumida Yoshio Sumida Atsushi Nakajima Hideyuki Hyogo Saiyu Tanaka Masafumi Ono Hideki Fujii Yuichiro Eguchi Masato Yoneda Takeshi Okanoue Yoshito Itoh Japan Study Group of NAFLD (JSG-NAFLD)

Research Article-Integrative Molecular Medicine (IMM)

April 06, 2015


Evidence-based medicine; climbing a mountain for a better decision-making

Mona O. Mohsen Ahmed M. Malki Hassan Abel Aziz

Review Article-Integrative Molecular Medicine (IMM)

April 12, 2015


Effects of CCCP on the expression of GABARAPL2 in C6 glioma cells

Yoshimitsu Kiriyama Airi Ozaki, Katsuhito Kino Hiromi Nochi

Research Article-Integrative Molecular Medicine (IMM)

April 27, 2015


Blood inorganic mercury is directly associated with glucose levels in the human population and may be linked to processed food intake

Renee Dufault Zara Berg Raquel Crider Roseanne Schnoll Larry Wetsit Wayne Two Bulls Steven G. Gilbert H.M. “Skip” Kingston Mesay Mulugeta Wolle G.M. Mizanur Rahman Dan R. Laks

Research Article-Integrative Molecular Medicine (IMM)

May 02, 2015


Shoulder dystocia among parous parturients: Birth weight differences of the largest prior vaginal delivery and index pregnancy

Suneet P. Chauhan Kenny Choi Everett F. Magann Sharon D. Keiser Jonathan F. Rehberg John C. Morrison

Research Article-Integrative Molecular Medicine (IMM)

May 06, 2015


Generation of inner ear hair cells in vitro from mouse embryonic stem cells

Geping Wu Ling Zhang Guangyin Xu Yan Yu Hongyan Zhu Yan Lv

Research Article-Integrative Molecular Medicine (IMM)

May 08, 2015


A critical evaluation of serum lipase and amylase as diagnostic tests for acute pancreatitis

Sarfaraz Jasdanwala Mark Babyatsky

Review Article-Integrative Molecular Medicine (IMM)

May 12, 2015


Age-related difference in nociceptive behavior of Cav2.1α1 mutant mice, rolling Nagoya

Ying Zhou Kimie Niimi Weidong Li Eiki Takahashi

Research Article-Integrative Molecular Medicine (IMM)

May 17, 2015


Discovery of a novel effect of electric field exposure on human plasma beta-endorphin and interleukin-12 levels: Insight into mechanisms of pain alleviation and defense against infection by electric field therapy

Yuzo Nakagawa-Yagi Hiroyuki Hara Yusuke Yoshida Atsushi Midorikawa Akikuni Hara

Research Article-Integrative Molecular Medicine (IMM)

May 17, 2015


Diagnosis of amyloid-positive mild cognitive impairment using structural magnetic resonance imaging: The worth of multiple regions of interest

Piers Vigers Akihiko Shiino Ikuo Tooyama

Research Article-Integrative Molecular Medicine (IMM)

May 26, 2015


The effect of an alkaline buffered creatine (Kre-Alkalyn®), on cell membrane behavior, protein synthesis, and cisplatin-mediated cellular toxicity

Jeff Golini

Research Article-Integrative Molecular Medicine (IMM)

May 28, 2015


Loss of FAM20A protein induces Amelogenesis Imperfecta in mice

Chunying An Shunji Kumabe Michiko Nakatsuka Katsura Ueda Yoshifumi Matsuda Kentaro Ueno Yasutomo Iwai

Research Article-Integrative Molecular Medicine (IMM)

May 28, 2015


Lipoprotein (a), a principle culprit: Relevance to pathobiology of hypertension, ischemic strokes and implications for novel therapeutic targets, a new puzzle found

Okom Nkili F. C. OFODILE

Review Article-Integrative Molecular Medicine (IMM)

June 04, 2015


Progesterone therapy attenuates fetal brain cytokine levels and improves survival/birth weights in infected rat pups

Christian M. Briery Carl H. Rose Kedra Wallace William A. Bennett Rick W. Martin John C. Morrison

Review Article-Integrative Molecular Medicine (IMM)

June 13, 2015


Color-imaging histodiagnostic approach for cancer

Akio Sugitachi Koki Otsuka Toshimoto Kimura Masanori Hakozaki Mizunori Yaegashi Megumu Kamishima Kohei Kume Yukimi Ohmori Satoshi Nishizuka Akira Sasaki

Research Article-Integrative Molecular Medicine (IMM)

June 14, 2015


Cellular stress after transferring human cornea from in vivo to in vitro milieu: A metabolomic approach

Tomasz Kryczka

Research Article-Integrative Molecular Medicine (IMM)

June 12, 2015


Metabolic changes in donor corneas during cold storage–challenging stereotypes

Tomasz Kryczka Jacek P. Szaflik Jerzy Szaflik Anna Midelfart

Research Article-Integrative Molecular Medicine (IMM)

June 15, 2015


Characterization and analysis of claudin-1 expression in colorectal cancer and its metastases: A pilot study

Wael Al Kattan Abderrahman Ouban Rehana Nawab Omar Al-Obaid

Research Article-Integrative Molecular Medicine (IMM)

June 22, 2015


Clinical applicability of glycated hemoglobin in the evolution of patients with hospital hyperglycemia

Beatriz Dal Santo Francisco Bonamichi João Eduardo Nunes Salles Carolina Ferraz Adriano Namo Cury Rubens Aldo Sargaço

Research Article-Integrative Molecular Medicine (IMM)

June 23, 2015


Single-nucleotide-polymorphism-and-cell-type-dependent-gene-expression-of-neuropeptide-Y2-receptor

Mio Okada Masayo Nagai Akiko Hamaue Maiko Mori Hidesuke Kaji

Research Article-Integrative Molecular Medicine (IMM)

June 26, 2015


Inhibition of Cav2.2-mediated signaling induces sensorimotor gating deficits

Ying Zhou Kimie Niimi Weidong Li Eiki Takahashi

Research Article-Integrative Molecular Medicine (IMM)

June 30, 2015


Proteomic network analysis of human uterine smooth muscle in pregnancy, labor, and preterm labor

Craig Ulrich David R. Quilici Karen A. Schlauch Iain L. O. Buxton

Research Article-Integrative Molecular Medicine (IMM)

July 08, 2015


Screening pre-diabetes and obese women in an early stage of renal dysfucntion from serum 25- hydroxy vitamin D and serum parathormone levels with age, body mass index and fast plasma glucose

Ernest Emilion Richard Emilion

Research Article-Integrative Molecular Medicine (IMM)

July 12, 2015


Genome-wide analysis of differentially expressed long noncoding RNAs induced by low shear stress in human umbilical vein endothelial cells

Shao-Liang Chen Zhi-Mei Wang Zuo-Ying Hu and Bing Li

Research Article-Integrative Molecular Medicine (IMM)

July 29, 2015


Human umbilical cord blood stem cells applied in therapy for ionizing radiation injury

Xinwen Zhang Yujun Xia Chenglong JI

Research Article-Integrative Molecular Medicine (IMM)

August 03, 2015


Clinical pathways of metastatic spinal cord compression: Orthopedics experience based on hospital admissions

Sharifa Ezat Wan Puteh Noraziani Khamis Sabarul Afian Mokhtar

Research Article-Integrative Molecular Medicine (IMM)

August 05, 2015


Antioxidant, antimicrobial and antitumor activity of bacteria of the genus Bifidobacterium, selected from the gastrointestinal tract of human

Prosekov A Dyshlyuk L Milentyeva I Sukhih S Babich O Ivanova S Pavskyi V Shishin M Matskova L

Research Article-Integrative Molecular Medicine (IMM)

August 06, 2015


Blockade of recombinant human IL-6 by tocilizumab suppresses matrix metalloproteinase-9 production in the C28/I2 immortalized human chondrocyte cell line

Evan C. Meszaros Wissam Dahoud Sam Mesiano Charles J. Malemud

Research Article-Integrative Molecular Medicine (IMM)

August 08, 2015


Aspects of interferons (IFNs) interfering with HCV-G1 response

Ilham T Qattan

Review Article-Integrative Molecular Medicine (IMM)

August 11, 2015


Purification of IFNγ-secreting, effector T lymphocytes that induce apoptosis in cancer cells

Adeeb AlZoubi Rahaf AlZoubi Fawzy AlSheyab Farah Khalifeh Mohammed El-Khateeb

Research Article-Integrative Molecular Medicine (IMM)

August 12, 2015


Effects of a Cav2.2 inhibitor on spatial and non-spatial short-term memory

Ying Zhou Kimie Niimi Weidong Li Eiki Takahashi

Research Article-Integrative Molecular Medicine (IMM)

August 22, 2015


Relationships of clinical response to relevant molecular signal during Phase I testing of Aurora Kinase A inhibitor: Retrospective assessment

John Nemunaitis Christopher Blend Gabriel Bien-Willner Meghan Degele Alyssa Roth Stacey Hayes Leah Plato Andrew Guo James Nemunaitis David B. Jackson Neil Senzer

Research Article-Integrative Molecular Medicine (IMM)

August 24, 2015


Impact of weight loss in metabolic profile with reeducation diet in obesity group

Beatriz Dal Santo Francisco Bonamichi Sheila Patricia Lopes Rocha Rafael Bonamichi dos Santos Nanci Merce Nilza Maria Scalissi João Eduardo Nunes Salles

Research Article-Integrative Molecular Medicine (IMM)

August 26, 2015


Association between miR-146a SNP rs2910164 and ischemic stroke in Asian population: a meta-analysis

Xue-qi YANG Jiao ZHANG

Research Article-Integrative Molecular Medicine (IMM)

September 05, 2015


Xenoantibodies to porcine non-galactose α 1,3 galactose antigens in non-human primates cross-react and cause apoptosis to human endothelial cells

Rafael Mañez Isabel Moscoso Cristina Costa Alberto Centeno Eduardo Lopez-Pelaez Natalia Suarez Nieves Domenech

Research Article-Integrative Molecular Medicine (IMM)

September 08, 2015


Cation-π interaction of N,N-Dimethyltryptamine in hydrochloric acid solution characteristic to gastric acid

Andrej Vidak Iva Movre Šapić Vladimir Dananić

Research Article-Integrative Molecular Medicine (IMM)

September 10, 2015


The role of sulforaphane on duchenne muscular dystrophy by activation of Nrf2

Cheng-Cao Sun Jing-Yu Pan Shu-Jun Li De-Jia Li

Mini Review-Integrative Molecular Medicine (IMM)

September 14, 2015


Hypothesis on a signalling system based on molecular vibrations of structure forming macromolecules in cells and tissues

Werner Jaross

Review Article-Integrative Molecular Medicine (IMM)

September 14, 2015


Elevated anthranilic acid plasma concentrations in type 1 but not type 2 diabetes mellitus

Gregory Oxenkrug Marieke van der Hart Paul Summergrad

Review Article-Integrative Molecular Medicine (IMM)

September 25, 2015


Role of Cav2.2-mediated signaling in depressive behaviors

Ying Zhou Kimie Niimi Weidong Li Eiki Takahashi

Research Article-Integrative Molecular Medicine (IMM)

October 05, 2015


Establishment of β-2 microglobulin deficient human iPS cells using CRISPR/Cas9 system

Takehito Sato Hisako Akatsuka Yoshiki Yamaguchi Keiko Miyashita Masafumi Tanaka Tetsuro Tamaki Masato Ohtsuka Minoru Kimura

Research Article-Integrative Molecular Medicine (IMM)

October 12, 2015


Microarray analysis of long non-coding RNA expression in Ankylosing Spondylitis

Weiguo Sui Huan Li Huiyan He Wen Xue Xin Zhao Yong Dai

Research Article-Integrative Molecular Medicine (IMM)

October 15, 2015


Beyond bone remodeling–emerging functions of osteoprotegerin in host defense and microbial infection

Michiyo Kobayashi-Sakamoto Riyoko Tamai Yusuke Kiyoura

Review Article-Integrative Molecular Medicine (IMM)

October 16, 2015


Clinical validity of our color-imaging histo-diagnosis for cancer

Akio Sugitachi Toshimoto Kimura Koki Otsuka Masanori Hakozaki Mizunori Yaegashi Megumu Kamishima Kohei Kume Satoshi Nishizuka Noriyuki Uesugi Tamotsu Sugai Akira Sasaki

Research Article-Integrative Molecular Medicine (IMM)

October 30, 2015


Enhanced recellularization of renal extracellular matrix scaffold under negative pressure

Satoshi Hachisuka Yuichi Sato Miki Yoshiike Ryuto Nakazawa Hideo Sasaki Tatsuya Chikaraishi

Research Article-Integrative Molecular Medicine (IMM)

October 31, 2015


A paediatric patient with AML M1 and a t(11;19)(q23;p13.1) rearrangement

Lisa Duffy Rong Gong Nyree Cole Donald R. Love Alice M. George

Research Article-Integrative Molecular Medicine (IMM)

November 02, 2015


Stilbene derivatives from melinjo extract have antioxidant and immune modulatory effects in healthy individuals

J. Luis Espinoza Dao Thi An1 Ly Quoc Trung Kayoko Yamada Shinji Nakao Takami

Research Article-Integrative Molecular Medicine (IMM)

November 05, 2015


Combined therapy using fetal stem cells and a complex of physical exercises in treatment of patients with amyotrophic lateral sclerosis

A.A. Sinelnyk M.O. Klunnyk M.P. Demchuk N.S. Sych O.V. Ivankova I.G. Matiyashchuk M.V. Skalozub A.V. Novytska K.I. Sorochynska

Research Article-Integrative Molecular Medicine (IMM)

November 13, 2015


Integration of major histocompatibility complex, methylation, and transcribed ultra-conserved regions analyses in uremia

Jinjun Qiu Huiyan He Weiguo Sui Dong’e Tang Yong Dai

Research Article-Integrative Molecular Medicine (IMM)

November 16, 2015


Prognostication of heart failure development and advance: the role of high-sensitive ST2

Alexander E. Berezin

Short Communication-Integrative Molecular Medicine (IMM)

November 16, 2015


Nasal hygiene in patients with end-stage renal disease

Zhao Fan Baiya Li

Research Article-Integrative Molecular Medicine (IMM)

November 20, 2015


EOLA1 inhibits lipopolysaccharide-induced vascular cell adhesion molecule-1 expression by association with MT2A in endothelial cells

Min Luo Weiling Len Xiaotian Lei Hao Meng Xinshou Ouyang Ziwen Liang

Research Article-Integrative Molecular Medicine (IMM)

November 21, 2015


Current situation of newborn screening for congenital hypothyroidism in China

Juan Liu Yonglin Liu Xia Li Fuyong Jiao

Editorial-Integrative Molecular Medicine (IMM)

November 21, 2015


The genetic variant of COX-2 acts as a potential risk factor of colorectal cancer: evidence from a meta-analysis based on 13461 individuals

Yan Pan Song Gao Qi Qi Luming Liu

Research Article-Integrative Molecular Medicine (IMM)

November 30, 2015


Volume 1

Inaugural Editorial for Integrative Molecular Medicine

Masayoshi Yamaguchi

Editorial-Integrative Molecular Medicine (IMM)

Jul 17, 2014


Role of nutritional factor menaquinone-7 in bone homeostasis and osteoporosis prevention

Masayoshi Yamaguchi

Review Article-Integrative Molecular Medicine (IMM)

Jul 23, 2014


Regucalcin, a novel regulatory protein implicated in obesity and diabetes

Masayoshi Yamaguchi

Review Article-Integrative Molecular Medicine (IMM)

Jul 23, 2014

High waist circumference - A potential risk factor for premature metabolic syndrome in women irrespective of menopausal status

Namrata Chhabra Kuldip Sodhi Sahiba Kukreja Sahil Chhabra Sarah Chhabra Kavish Ramessur

Research Article-Integrative Molecular Medicine (IMM)

September 20, 2014


Detection of DNA methylation of gastric juice-derived exosomes in gastric cancer

Yoshida Y Yamamoto H Morita R OikawaR Matsuo Y Maehata T Nosho K Watanabe Y Yasuda H Itoh F

Research Article-Integrative Molecular Medicine (IMM)

September 29, 2014


Quest for the development of tooth root/periodontal ligament complex by tissue engineering

Hidefumi Maeda Akifumi Akamine

Review Article-Integrative Molecular Medicine (IMM)

October 01, 2014


Serum concentration of bone morphogenetic proteins (BMPs) is not linked to serum anti-mullerian hormone (AMH) level

Sayaka Ogura-Nose Osamu Yoshino Ikumi Akiyama Yasushi Hirota Tetsuya Hirata Miyuki Harada M
Hisahiko Hiroi KaoriKoga Shigeru Saito Yutaka Osuga Tomoyuki Fujii

Research Article-Integrative Molecular Medicine (IMM)

October 03, 2014


Non-targeted human plasma metabolomics reveals the changes in oleoylethanolamide, a lipid-derived signaling molecule, by acute exposure of electric field

Nakagawa-Yagi Y Hara H Fujimori T Yamaguchi T Midorikawa A Hara A

Research-Integrative Molecular Medicine (IMM)

October 14, 2014

Disulfide-bridged proteins with potential for medical applications: therapeutic relevance, sample preparation and structure – function relationships

Michiro Muraki

Review Article-Integrative Molecular Medicine (IMM)

November 05, 2014


Suppressive effects of EB virus infection on HER2 expression in gastric cancer cells

Ryo Morita Yasutaka Sukawa Hiroyuki Yamamoto Yoshihito Yoshida Ritsuko Oikawa Yasumasa Matsuo Tadateru Maehata Katsuhiko Nosho Yoshiyuki Watanabe Hiroshi Yasuda Fumio Itoh

Research Article-Integrative Molecular Medicine (IMM)

November 05, 2014


Development of a novel approach to enhance the solubility of ftibamzone formulation

Ofonime Udofot Kristen Jaruszewski Shawn Spencer Edward Agyare

Research Article-Integrative Molecular Medicine (IMM)

November 07, 2014


A peptide profile of amniotic fluid in a fetal lamb model of gastroschisis

Kei Ohyama Toshiyuki Sato Kunihide Tanaka Shutaro Manabe Hideki Nagae Mitsumi Arito Nobuko Iizuka Shigeki Kojima Kazuki Omoteyama Yasuji Seki Manae S. Kurokawa Naoya Suematsu Kazuki Okamoto Kevin C. Pring Tomohiro Kato Hiroaki Kitagawa

Research Article-Integrative Molecular Medicine (IMM)

November 17, 2014


Diabetes mellitus is important as a risk factor of atrial fibrillation

Kenichi Aizawa Jun Fujii Yoshinori Seko

Research Article-Integrative Molecular Medicine (IMM)

November 27, 2014


The effects of anesthesia and fetal surgery on the early ovine fetus

Shutaro Manabe Hiroaki Kitagawa Kei Ooyama Yasuji Seki Hideki Nagae Masayuki Takagi Junki Koike Jane Zuccollo Kevin C Pringle

Research Article-Integrative Molecular Medicine (IMM)

December 27, 2014

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Special Issues


Breast Cancer

Editor Affiliation:

Ricardo H. Alvarez
Cancer Treatment Centers of America

Submission date: November 30, 2016
Publication date: January 31, 2017

  • Obstacles to the Medical Revolution

    Editor Affiliation:
    David W. Moskowitz
    MD FACP, Founder and CEO, GenoMed, Inc. (www.genomed.com)

    Submission date: June 30, 2016
    Publication date: August 03, 2016

    Description of the Special Issue: It's widely agreed that molecular medicine will revolutionize the practice of medicine. Few people realize that it's long overdue. Linus Pauling and colleagues published "Sickle Cell Anemia, a Molecular Disease," in the November 1949 issue of Science, but the treatment for sickle cell disease remains unsatisfactory over 65 years later.

    What has been holding up the medical revolution? Papers are solicited on this general topic. They may address any of the following topics, or another that the author feels is equally important:

    1. Problems solving polygenic diseases
    2. Is there a better approach to oncology?
    3. Drug discovery and development in the 21st century
    4. Shifting the healthcare industry to prevention: economic and legal challenges
    5. The role of public health authorities
    6. The role of the media
    7. The role of investors