Follow us on :



Integrative Cancer Science and Therapeutics (ICST)

Online ISSN: 2056-4546

Vicente Notario (Editor in Chief)

Georgetown University

Integrative Cancer Science and Therapeutics (ICST) is an open access, peer-reviewed online journal interested in attracting high-quality original research and reviews that present or highlight significant advances in all areas of cancer and related biomedical science. The Journal is concerned with basic, translational and clinical research, across different disciplines and areas, enhancing insight in understanding, prevention, diagnosis and treatment of cancer. The journal also prioritizes clinical trials evaluating new treatments, accompanied by research on pharmacology and molecular alterations or biomarkers that predict response or resistance to treatment.

Integrative Cancer Science and Therapeutics welcomes submission of papers both at the molecular, subcellular, cellular, organ, and organism level, and of clinical proof-of-concept and translational studies. Topics of interest include, but are not limited to: novel basic cancer research discoveries, cell and tumor biology, animal models, metastasis, cancer antigens and the immune response to them, cellular signalling and molecular biology, epidemiology, genetic and molecular profiling of cancer and molecular targets, cancer stem cells, cancer-associated pathways (including cell-cycle regulation; cell death; chromatin regulation; DNA damage and repair; gene and RNA regulation; genomics; oncogenes and tumor suppressors; and signal transduction), molecular virology and vaccine- and antibody-based cancer therapies, and other cancer-related research.

Integrative Cancer Science and Therapeutics provides an important forum for exchange of ideas, concepts and findings in any area of cancer and related biomedical science. The online appearance of Integrative Cancer Science and Therapeutics allows the immediate publication of accepted articles and the presentation of large amounts of data and supplemental information to ensure that new research is disseminated as efficiently and quickly as possible to the scientific community.

Manuscripts may be submitted as Original Articles, Rapid and Short Communications, or Reviews, Mini-review, Case Reports, Opinion, Letters to the Editor and Editorials. Integrative Cancer Science and Therapeutics is proud of its fast Reviewing and Editorial Decision system. Manuscripts are normally evaluated by three members from an international panel of reviewers and, in most cases, we provide a first editorial decision within 21 days of receipt.

ICST welcomes direct submissions of manuscripts from authors. You can submit your manuscript to : submissions@oatext.com; alternatively to : masayoshi@oatext.com

Vicente Notario


Vicente Notario graduated with a B.Sc. degree from the University of Salamanca, Spain, in 1974, and received his Ph.D. in Biology from the same institution in 1977. After completing post-doctoral training in the Department of Biochemistry of the University of Cambridge, England, and the U.S. National Cancer Institute, he joined the Department of Biochemistry at the Georgetown University Medical Center (G.U.M.C.) as a Research Assistant Professor, in 1986. Currently, Dr. Notario is Professor in the Departments of Radiation Medicine and of Biochemistry and Molecular & Cellular Biology. He is also Director of the Division of Radiation Research in the Department of Radiation Medicine. Dr. Notario has been Leader of the Radiation Biology & DNA Repair Program and the Molecular Targets & Therapeutic Resistance Program of the Lombardi Comprehensive Cancer Center, at the G.U.M.C. for over twenty years.

His laboratory has focused on understanding molecular and cellular mechanisms of cancer initiation and progression as well as those involved in the acquisition of resistance to anti-cancer therapy, with emphasis on pathways that may be exploited to improve the treatment of metastatic cancers and to sensitize human tumors to chemotherapeutic drugs and radiation therapies. In addition, the Notario laboratory studies molecular targets and pathways that may enhance the sensitivity to radiotherapy of Ewing’s sarcoma, a very aggressive type bone tumors that predominantly affect children and young adults. Related areas of research explore the anti-tumorigenic activity of the PEDF protein using various experimental systems for experimental carcinogenesis as well as the possible anti-cancer actions of human dietary components. Dr. Notario has authored over 140 publications and has been continuously funded by the U.S. National Cancer Institute since 1986.

Editorial Board

Yu-Jui Yvonne Wan

Professor and Vice Chair of Research
Department of Medical Pathology & Laboratory Medicine
University of California, Davis Medical Center

Glen J. Weiss

Clinical Associate Professor
Translational Genomics Research Institute (TGen)
Clinical Assistant Professor of Medicine
The University of Arizona College of Medicine-Phoenix
Director of Clinical Research
Cancer Treatment Centers of America

Ben Warner

Clinical Associate Professor
Department of General Practice and Dental Public Health
The University of Texas


Rajagopal Ramesh

Professor of Pathology
Director, Experimental Therapeutics and Translational Cancer Medicine
University of Oklahoma Health Sciences Center

Donald J. Alcendor

Assistant Professor of Cancer Biology
Meharry Medical College
Adjunct Assistant Professor of Cancer Biology
Vanderbilt School of Medicine

Toru Ouchi

Professor of Oncology
Department of Cancer Genetics
Roswell Park Cancer Institute


Arun K. Rishi

Professor
Department of Oncology and Internal Medicine
Karmanos Cancer Institute
Wayne State University

Moshe Talpaz

Associate Chief
Division of Hematology/Oncology
University of Michigan Health System

Ming Zhang

Associate Professor
Northwestern University Feinberg School of Medicine
Department of Biochemistry
Robert H. Lurie Comprehensive Cancer Center, and Center for Genetic Medicine


Vicente Notario

Professor
Department of Radiation Medicine
Leader, Molecular Oncology Program
Lombardi Comprehensive Cancer Center
Georgetown University Medical Center

Charlie Ma

Professor Vice Chairman, Department of Radiation Oncology
Director, Radiation Physics
Fox Chase Cancer Center

Pranela Rameshwar

Professor
Medicine-Hematology/Oncology
Rutgers-New Jersey Medical School


Awad Shamma

Division of Oncology and Molecular Biology,
Cancer and Stem Cell Research Program
Kanazawa University Cancer Research Institute

Rebecca B. Riggins

Assistant Professor
Breast Cancer Program
Lombardi Comprehensive Cancer Center
Georgetown University Medical Center

Lucio Miele

Professor of Medicine and Director for Inter-Institutional Programs
LSU Stanley Scott Cancer Center and Louisiana Cancer Research Consortium


Leonidas G. Koniaris

Professor of Surgery (Surgical Oncology)
Vice Chair of Research
IU Health University Hospital, Surgery OP Clinic
Indiana University

Alfio Ferlito

Director of the Department of Surgical Sciences
Professor and Chairman of the ENT Clinic
University of Udine School of Medicine

Masakazu Toi

Professor
Breast Surgery
Kyoto University


Kazuya Fukuoka

Associate Professor Department of Medical Oncology, Sakai Hospital, Kinki University Faculty of Medicine, Japan

Makoto Takahama

Director and Chairman Department of General Thoracic Surgery Osaka City General Hospital, Japan

Jitsuo Usuda

Professor, Department of Thoracic Surgery Nippon Medical School, Japan


Yoshitane Tsukamoto

Associate Professor
Department of Surgical Pathology
Hyogo College of Medicine, Japan

Yasuhiro Koh

Assistant Professor
Third Department of Internal Medicine
Wakayama Medical University, Japan

Akito Hata

Deputy Head Physician
Division of Integrated Oncology
Institute of Biomedical Research and Innovation, Japan


Kazushi Inoue

Associate Professor
Pathology - Tumor Biology
Wake Forest University School of Medicine
USA

Early View

Volume 4, Issue 1


Will be update soon.

Current Issue

Volume 3, Issue 6


Electrical impedance spectroscopy for breast cancer diagnosis: Clinical study

Z. Haeri M. Shokoufi M. Jenab R. Janzen F.Golnaraghi

Research Article-Cancer Science and Therapeutics (ICST)

December 16, 2016


Historical highlights on cancer invading the portal vein

Wilson I. B. Onuigbo

Opinion-Cancer Science and Therapeutics (ICST)

December 19, 2016


Cytokines and immune response in vasculitis of peripheral nervous system: Tumor necrosis factor-alpha and pro-inflammatory cytokines in vaculitis of peripheral nervous system: A comparative immunohistochemical study on systemic and non-systemic vasculitic neuropathy

Giovanni Antioco Putzu

Research Article-Cancer Science and Therapeutics (ICST)

December 23, 2016


Cardiac toxicities associated with cancer therapy

Eric Chang Sanjay R Jain

Review Article-Cancer Science and Therapeutics (ICST)

December 24, 2016


Exploration of food materials and components showing the suppressing effect on absorption of strontium and the promoting effect on excretion of cesium in vivo

Yuya Uehara Kana Ishizuka Yuko Shimamura Michiko Yasuda Kayoko Shimoi Shuichi Masuda

Research Article-Cancer Science and Therapeutics (ICST)

December 26, 2016


Large cell neuroendocrine carcinoma (LCNEC) of the ovary: A case report and review of the literature

Allyson Jang Jordan M. Newell Rebecca Phaeton Joshua P. Kesterson

Case Report-Integrative Cancer Science and Therapeutics (ICST)

Dec 28, 2016


An intracranial dermoid tumour with large right parietal infarct- A rare case report

Sarkar S Islam MM Avijit D Hossen MK Dasgupta A Saha S Sazib SMF Khan MN

Case Report-Integrative Cancer Science and Therapeutics (ICST)

Dec 28, 2016


High dose intravenous vitamin c and metastatic pancreatic cancer: Two cases

Michael J. González Miguel J. Berdiel Jorge R Miranda-Massari Desireé López Jorge Duconge Joshua L. Rodriguez Pedro Adrover c

Case Report-Integrative Cancer Science and Therapeutics (ICST)

Dec 29, 2016


Thin melanoma and sentinel lymph node biopsy: A difficult relationship between them

JC Rodriguez Otero R Fernández Bussy A Bergero M Gorosito G Salerni MS Dagatti R Villavicencio R Staffieri SM Batallés V Milatich J Rodriguez Otero SM Pezzotto

Research Article-Integrative Cancer Science and Therapeutics (ICST)

Dec 29, 2016


Microenvironment and its role in acquiring drug resistance of leukemia treatment

Malak Yahia Mohammed Qattan

Mini- Review-Integrative Cancer Science and Therapeutics (ICST)

Dec 30, 2016


Previous Issue

Volume 3, Issue 5


M2-like macrophages and tumor-associated macrophages: overlapping and distinguishing properties en route to a safe therapeutic potential

Ofer Guttman Eli C. Lewis

Review Article-Cancer Science and Therapeutics (ICST)

August 29, 2016


Multicentral meningothelial meningioma: a case of death

Mansueto Gelsomina Emanuele Capasso Antonio Lombardi Pieri Maria Claudio Buccelli

Case Report-Cancer Science and Therapeutics (ICST)

September 12, 2016


Should we continue intra-peritoneal chemotherapy in advanced ovarian cancer patients?

Gary Altwerger Gulden Menderes Jonathan D. Black Masoud Azodi

Review Article-Cancer Science and Therapeutics (ICST)

September 17, 2016


The clinical characteristics of oral squamous cell carcinoma in patients attending the Medunsa Oral Health Centre, South Africa

Bouckaert M Munzhelele TI Lemmer J Khammissa RAG

Research Article-Cancer Science and Therapeutics (ICST)

October 12, 2016


Distinguishing malignant from benign prostate using content of 17 chemical elements in prostatic tissue

Vladimir Zaichick Sofia Zaichick

Research Article-Cancer Science and Therapeutics (ICST)

October 22, 2016


Choledochal cysts- Classification, physiopathology, and clinical course

Fatih Altıntoprak Mustafa Yener Uzunoğlu Enis Dikicier İsmail Zengin

Research Article-Cancer Science and Therapeutics (ICST)

October 24, 2016


Clinical applications of mouse models for breast cancer engaging HER2/neu

Elizabeth A. Fry Pankaj Taneja Kazushi Inoue

Review Article-Cancer Science and Therapeutics (ICST)

October 28, 2016


A review of invasive lobular carcinoma of the breast: Should it be treated like invasive ductal carcinoma?

Lee Joycelyn Jie Xin Lee Guek Eng

Mini Review-Cancer Science and Therapeutics (ICST)

October 29, 2016


Archive


Volume 3

Electrical impedance spectroscopy for breast cancer diagnosis: Clinical study

Z. Haeri M. Shokoufi M. Jenab R. Janzen F.Golnaraghi

Research Article-Cancer Science and Therapeutics (ICST)

December 16, 2016


Historical highlights on cancer invading the portal vein

Wilson I. B. Onuigbo

Opinion-Cancer Science and Therapeutics (ICST)

December 19, 2016


Cytokines and immune response in vasculitis of peripheral nervous system: Tumor necrosis factor-alpha and pro-inflammatory cytokines in vaculitis of peripheral nervous system: A comparative immunohistochemical study on systemic and non-systemic vasculitic neuropathy

Giovanni Antioco Putzu

Research Article-Cancer Science and Therapeutics (ICST)

December 23, 2016


Cardiac toxicities associated with cancer therapy

Eric Chang Sanjay R Jain

Review Article-Cancer Science and Therapeutics (ICST)

December 24, 2016


Exploration of food materials and components showing the suppressing effect on absorption of strontium and the promoting effect on excretion of cesium in vivo

Yuya Uehara Kana Ishizuka Yuko Shimamura Michiko Yasuda Kayoko Shimoi Shuichi Masuda

Research Article-Cancer Science and Therapeutics (ICST)

December 26, 2016


Large cell neuroendocrine carcinoma (LCNEC) of the ovary: A case report and review of the literature

Allyson Jang Jordan M. Newell Rebecca Phaeton Joshua P. Kesterson

Case Report-Integrative Cancer Science and Therapeutics (ICST)

Dec 28, 2016


An intracranial dermoid tumour with large right parietal infarct- A rare case report

Sarkar S Islam MM Avijit D Hossen MK Dasgupta A Saha S Sazib SMF Khan MN

Case Report-Integrative Cancer Science and Therapeutics (ICST)

Dec 28, 2016


High dose intravenous vitamin c and metastatic pancreatic cancer: Two cases

Michael J. González Miguel J. Berdiel Jorge R Miranda-Massari Desireé López Jorge Duconge Joshua L. Rodriguez Pedro Adrover c

Case Report-Integrative Cancer Science and Therapeutics (ICST)

Dec 29, 2016


Thin melanoma and sentinel lymph node biopsy: A difficult relationship between them

JC Rodriguez Otero R Fernández Bussy A Bergero M Gorosito G Salerni MS Dagatti R Villavicencio R Staffieri SM Batallés V Milatich J Rodriguez Otero SM Pezzotto

Research Article-Integrative Cancer Science and Therapeutics (ICST)

Dec 29, 2016


Microenvironment and its role in acquiring drug resistance of leukemia treatment

Malak Yahia Mohammed Qattan

Mini- Review-Integrative Cancer Science and Therapeutics (ICST)

Dec 30, 2016


M2-like macrophages and tumor-associated macrophages: overlapping and distinguishing properties en route to a safe therapeutic potential

Ofer Guttman Eli C. Lewis

Review Article-Cancer Science and Therapeutics (ICST)

August 29, 2016


Multicentral meningothelial meningioma: a case of death

Mansueto Gelsomina Emanuele Capasso Antonio Lombardi Pieri Maria Claudio Buccelli

Case Report-Cancer Science and Therapeutics (ICST)

September 12, 2016


Should we continue intra-peritoneal chemotherapy in advanced ovarian cancer patients?

Gary Altwerger Gulden Menderes Jonathan D. Black Masoud Azodi

Review Article-Cancer Science and Therapeutics (ICST)

September 17, 2016


The clinical characteristics of oral squamous cell carcinoma in patients attending the Medunsa Oral Health Centre, South Africa

Bouckaert M Munzhelele TI Lemmer J Khammissa RAG

Research Article-Cancer Science and Therapeutics (ICST)

October 12, 2016


Distinguishing malignant from benign prostate using content of 17 chemical elements in prostatic tissue

Vladimir Zaichick Sofia Zaichick

Research Article-Cancer Science and Therapeutics (ICST)

October 22, 2016


Choledochal cysts- Classification, physiopathology, and clinical course

Fatih Altıntoprak Mustafa Yener Uzunoğlu Enis Dikicier İsmail Zengin

Research Article-Cancer Science and Therapeutics (ICST)

October 24, 2016


Clinical applications of mouse models for breast cancer engaging HER2/neu

Elizabeth A. Fry Pankaj Taneja Kazushi Inoue

Review Article-Cancer Science and Therapeutics (ICST)

October 28, 2016


A review of invasive lobular carcinoma of the breast: Should it be treated like invasive ductal carcinoma?

Lee Joycelyn Jie Xin Lee Guek Eng

Mini Review-Cancer Science and Therapeutics (ICST)

October 29, 2016


Lymphorrhea in gastric cancer patients

Bandar Ali

Short Communication-Integrative Cancer Science and Therapeutics (ICST)

May 30, 2016


Application of molecular targeted therapy for refractory metastatic thyroid cancers

Timothy Allen Lee Meller

Review Article-Integrative Cancer Science and Therapeutics (ICST)

June 17, 2016


The role of myeloid-derived suppressor cells in the relationship between chronic obstructive pulmonary disease and lung cancer

Sergio Scrimini Jaume Pons Jaume Sauleda

Review Article-Integrative Cancer Science and Therapeutics (ICST)

June 23, 2016


Characterizing heterogeneic tumor profiles with an integrated companion diagnostics approach

Sergio Scrimini Jaume Pons Jaume Sauleda

Review Article-Integrative Cancer Science and Therapeutics (ICST)

July 01, 2016


Cytoreductive surgery and heated intrathoracic chemotherapy for thoracic extension of Pseudomyxoma peritonei

Mathew P. Doyle Claudia I. Villanueva Samuel Davies Gary G. Fermanis Matthew D. Horton David L. Morris

Review Article-Integrative Cancer Science and Therapeutics (ICST)

July 03, 2016


Peri-tumoral neural niche in brain metastasis from breast cancer

Rahul Jandial Khairul I Ansari

Image Articl-Cancer Science and Therapeutics (ICST)

July 04, 2016


Microorganisms and cancer of the oral cavity

Kaoru Kusama Harumi Inoue Yuji Miyazaki Kentaro Kikuchi Hideaki Sakashita Kuniyasu Ochiai

Review Article-Cancer Science and Therapeutics (ICST)

July 08, 2016


Genetic determinants of psychic resilience after a diagnosis of cancer

Mette Christensen Antonio Drago

Review Article-Cancer Science and Therapeutics (ICST)

July 25, 2016


Acetogenins of Annona muricata leaves: Characterization and potential anticancer study

Nik Nurul Najihah Nik Mat Daud Harisun Ya’akob Mohamad Norisham Mohamad Rosdi

Research Article-Cancer Science and Therapeutics (ICST)

Aug 14, 2016


The rosebud- twenty-five years of tumor dormancy mimicks locally advanced non-small cell lung cancer

D. Staudenmann M. Gugger Ph. Dumont St. Zimmerman

Case Report-Cancer Science and Therapeutics (ICST)

Aug 23, 2016


BH3 mimetics: Their action and efficacy in cancer chemotherapy

Wataru Nakajima Nobuyuki Tanaka

Review Article-Integrative Cancer Science and Therapeutics (ICST)

April 26, 2016


11β-hydroxysteroid dehydrogenase type II: a Potential target for prevention of colonic tumorigenesis

Xin Wang Raymond C. Harris Ming-Zhi Zhang

Review Article-Integrative Cancer Science and Therapeutics (ICST)

April 29, 2016


Discussion on the tumor treatment of traditional chinese medicine:Discover the new therapeutic strategy

Xiaojuan Sun Fucheng Hu

Review Article-Integrative Cancer Science and Therapeutics (ICST)

April 29, 2016


Modulation of 5-Aminolevulinic acid mediated photodynamic therapy induced cell death in a human lung adenocarcinoma cell line

Teijo MJ Diez B Batlle A Haydée Fukuda

Research Article-Integrative Cancer Science and Therapeutics (ICST)

April 29, 2016


Integrative approaches in breast cancer patients: A mini-review

Stefano Magno Filippone Alessio Assunta Scaldaferri Virgilio Sacchini Federica Chiesa

Review Article-Integrative Cancer Science and Therapeutics (ICST)

May 05, 2016


Macrophages directed approaches are paramount for effective cancer immunotherapies

Vinod Nadella Sandhya Singh Hridayesh Prakash

Review Article-Integrative Cancer Science and Therapeutics (ICST)

May 05, 2016


Primary vaginal melanoma in the setting of mucosal melanosis - A case report and literature review

Deirdre Kelly Jack Gleeson Geoffrey Watson Graham Woods Connor O’Keane John Mc Caffrey

Case Report-Integrative Cancer Science and Therapeutics (ICST)

May 07, 2016


Kikuchi-Fujimoto necrotizing lymphadenitis: A rare case of generalized lymphadenopathy

Charlotte Lansky Hasaam Sheikh Mohamad Lazkani Cheryl O’Malley

Research Article-Integrative Cancer Science and Therapeutics (ICST)

May 09, 2016


Placenta-specific protein 1 (PLAC1) is a unique onco-fetal-placental protein and an underappreciated therapeutic target in cancer

Eric J. Devor

Review Article-Integrative Cancer Science and Therapeutics (ICST)

May 09, 2016


An overview of integrative analysis in cancer studies

Shinuk Kim Taesung Park

Review Article-Integrative Cancer Science and Therapeutics (ICST)

May 10, 2016


A single patient study of high dose isoflavones to enhance gemzar chemotherapy in post resection and post chemoradiation adjuvant treatment of pancreatic adenocarcinoma

Adam J. Nehr III Barbara J. Nehr

Case Report-Integrative Cancer Science and Therapeutics (ICST)

February 25, 2016


Adrenomedullin in pancreatic carcinoma: A case-control study of 22 patients

D'Angelo Francesco Letizia Claudio Antolino Laura La Rocca Mara Aurello Paolo Ramacciato Giovanni

Research Article-Integrative Cancer Science and Therapeutics (ICST)

March 14, 2016


The high effect of chemomobilization with high-dose topside and G-CSF in autologous hematopoietic peripheral blood stem cell transplantation (Single centre experience)

Sebnem Izmir Guner Mustafa Teoman Yanmaz Ahmet Selvi Cıgdem Usul

Research Article-Integrative Cancer Science and Therapeutics (ICST)

March 21, 2016


An importance of clinical proteomics for personalized medicine of lung cancer subtypes

Yasufumi Kato Toshihide Nishimura Jun Matsubayashi Kinya Furukawa Masaharu Nomura Kiyonaga Fujii Haruhiko Nakamura Harubumi Kato

Review Article-Integrative Cancer Science and Therapeutics (ICST)

March 25, 2016


Erosion of bowel by catheter of peritoneal access device during intraperitoneal chemotherapy: A case report and PRISMA-driven systematic review

Hung-Hsin Lin Hou-Hsuan Cheng Yi Chang Yen-Hou Chang Chi-Mu Chuang

Review Article-Integrative Cancer Science and Therapeutics (ICST)

March 28, 2016


Immunotherapy and colon cancer

Timothy Allen Abdullateef Al-Hadeethi

Review Article-Integrative Cancer Science and Therapeutics (ICST)

April04, 2016


MRI-guided radiotherapy: Opening our eyes to the future

Amar U. Kishan Percy Lee

Review Article-Integrative Cancer Science and Therapeutics (ICST)

April 06, 2016


Imaging in animal models

Eika Webb Ming Yuan Nicholas R Lemoine Yaohe Wang

Review Article-Integrative Cancer Science and Therapeutics (ICST)

April 08, 2016


Toll-like receptors and breast cancer

Lijie Sun Qiuli Jiang Yifan Zhang Hongbin Liang Huan Ren Dekai Zhang

Review Article-Integrative Cancer Science and Therapeutics (ICST)

April 25, 2016


The possible role of embryonic polarity axes for the normalization of tissue function induced by the interaction between human bilateral parts

Ming Cheh Ou Dennis Ou Chung Chu Pang

Research Article-Integrative Cancer Science and Therapeutics (ICST)

December 21, 2015


A short-term retrospective analysis of the clinical, histopathological and immunohistochemical aspects in endometrial malignancy

Tiberiu Augustin Georgescu Monica Cîrstoiu Mariana Costache Anca Lăzăroiu Adrian Dumitru

Research Article-Integrative Cancer Science and Therapeutics (ICST)

January 11, 2016


A case of advanced hepatocellular carcinoma cured with antiviral therapy and sorafenib

Steven Krawitz Flavius Guglielmo Hie-Won Hann

Case Report-Integrative Cancer Science and Therapeutics (ICST)

January 15, 2016


Corticosteroid-induced case of a lightning pheochromocytoma crisis:Insight into glucocorticoid receptor expression

Marie-France Dupont Marie-Claude Battista Émilie Comeau Myrna Atallah-Chababi Patrice Perron 5andMartine Chamberland

Case Report-Integrative Cancer Science and Therapeutics (ICST)

January 23, 2016


Subjective and objective evaluation of voice and pulmonary function in partial laryngectomised patients

Mehmet Gökhan Demir Mustafa Paksoy Arif Şanlı Sevtap Akbulut Sedat Aydın Hüseyin Baki Yılmaz Mehmet Bilgin Eser

Research Article-Integrative Cancer Science and Therapeutics (ICST)

January 30, 2016


Comparison of exposure levels of carotid artery in T1-2 glottic cancer patients undergoing radiotherapy with different modalities: A simulation-based dosimetric study

Gonca Hanedan Uslu Emine Canyilmaz Fatma Colak Burcin Hazeral Ahmet Yasar Zengin Hüseyin Göçmez Adnan Yoney

Research Article-Integrative Cancer Science and Therapeutics (ICST)

January 30, 2016


Management of hypercalcemia of malignancy

Sonia Amin Thomas (Sonia Patel) Soo-Hwan Chung

Review Article-Integrative Cancer Science and Therapeutics (ICST)

February 06, 2016


Metformin associates with lower on colorectal neoplastic risk in African American diabetic patients

AnahitaShahnazi Armana Saeed Gail Nunlee-Bland Yasin Mustafa Hassan Brim Mehdi Nouraie Hassan Ashktorab

Research Article-Integrative Cancer Science and Therapeutics (ICST)

February 08, 2016


Obesity as a risk factor for prostate cancer: A clinical review

Tushar Trivedi Marsha Samson Olubunmi Orekoya

Review Article-Integrative Cancer Science and Therapeutics (ICST)

February 11, 2016


Diabetes-associated dysregulated cytokines and cancer

Yong Wu Yunzhou Dong Yanjun Liu Jay Vadgama

Review Article-Integrative Cancer Science and Therapeutics (ICST)

February 15, 2016


Volume 2

Alpha1-antitrypsin, an endogenous immunoregulatory molecule: distinction between local and systemic effects on tumor immunology

Ofer Guttman Gabriella S Freixo-Lima Eli C Lewis

Review Article-Integrative Cancer Science and Therapeutics (ICST)

October 24, 2015


Evaluation of the impact of treatment delays and dose reductions in human ovarian cancer orthotopic mouse models

Scott Mosley Jing-Hong Chen Anjali Gaikwad Elizabeth K. Nugent Judith A. Smith

Research Article-Integrative Cancer Science and Therapeutics (ICST)

October 27, 2015


Comparing Chinese and American oncology practice patterns using precision therapy for non-small cell lung cancer

Zhang Ming HaoXinbao Han LiangFu Hu Honglin AoRui Zhu Xueqiang He Yangke Chen Lin Ming Zeng

Clinical Survey-Integrative Cancer Science and Therapeutics (ICST)

October 31, 2015


Monitoring Bip promoter activation during cancer cell growth by bioluminescence imaging at the single-cell level

Tomohisa Horibe Aya Torisawa Ryohsuke Kurihara Ryutaro Akiyoshi Yoko Hatta-Ohashi Hirobumi Suzuki Koji Kawakami

Research Article-Integrative Cancer Science and Therapeutics (ICST)

November03, 2015


Risk factors for cost-related medication non-adherence among older patients with cancer

James X. Zhang David O. Meltzer

Research Article-Integrative Cancer Science and Therapeutics (ICST)

November 06, 2015


Then there were none!

Veronica J. James Judith M. O'Malley Ford Jason Buttigieg

Letter to Editor-Integrative Cancer Science and Therapeutics (ICST)

December01, 2015


Pseudomyxoma peritonei, a rare tumors of the abdomen: Palliative treatment and response to low-dose capecitabine and/or bevacizumab

Stefanis Aristotelis Albertsson Maria

Case Report-Integrative Cancer Science and Therapeutics (ICST)

December04, 2015


Interprofessional care to improve patient-centered approach in breast cancer: a case-report regarding the management of concomitant psychiatric symptomatology

Paola Arnaboldi Serena Oliveri Gabriella Pravettoni

Case Report-Integrative Cancer Science and Therapeutics (ICST)

December 10, 2015


Systemic inflammation in malignant pleural mesothelioma: Is neutrophyl-to-lymphocyte ratio a prognostic index?

Felice MucilliFelice Mucilli Pierpaolo Camplese Luigi Guetti Barbara Maggi Marco Prioletta Mirko Barone Antonia Rizzuto Rosario Sacco

Research Article-Integrative Cancer Science and Therapeutics (ICST)

December 15, 2015


Oncogenic mutational/epigenetic events: Deterministic, stochastic or random: Implications for hypoxic cancer cells and tumor heterogeneity

Anderson KM Rubenstein M Guinan P Patel MK

Research Article-Integrative Cancer Science and Therapeutics (ICST)

January 05, 2015


Fatigue in patients with colorectal cancer treated with capecitabine and oxaliplatin

Sá Lilian A Vettori Josiane C Moreira Cláudia LR Leandro Miraya S Tirapelli Daniela PC Perdoná Gleici SC Souza Hayala CC Oliveira Harley F Santos Fabiana N Rapatoni Liane Ribeiro Karen B Almeida Thiago CL Feres Omar Rocha José JRR Peria Fernanda M

Research Article-Integrative Cancer Science and Therapeutics (ICST)

January 27, 2015


Expression and regulation of bone morphogenetic protein 4 in hepatocellular carcinoma

Xiaotong Wang Qingguo Wang Weisi Kong Gerald Y Minuk Frank J Burczynski Emmanuel Ho Yuewen Gong

Research Article-Integrative Cancer Science and Therapeutics (ICST)

January 29, 2015


The origin of circumscribed necroses and perinecrotic niches in glioblastoma multiforme: An additional hypothesis

Davide Schiffer Laura Annovazzi Marta Mazzucco Marta Mellai

Mini Review-Integrative Cancer Science and Therapeutics (ICST)

February 03, 2015


Shedding by ADAM10 and ADAM17 is associated with progression of adult T-cell leukemia/lymphoma

Shigeki Takemoto Tomohiro Kozako Ratiorn Pornkuna

Short Communication-Integrative Cancer Science and Therapeutics (ICST)

February 05, 2015


Delphinidin and cyanidin exhibit antiproliferative and apoptotic effects in MCF7 human breast cancer cells

Jessica Tang Emin Oroudjev Leslie Wilson George Ayoub

Research Article-Integrative Cancer Science and Therapeutics (ICST)

February 09, 2015


Effects of Chk1 inhibitor or paclitaxel on cisplatin-induced cell-cycle kinetics and survival in parental and cisplatin-resistant HeLa cells expressing fluorescent ubiquitination-based cell cycle indicator (Fucci)

Chisato Yamada Atsushi Kaida Kohei Okuyama Kiyoshi Harada Masahiko Miura

Research Article-Integrative Cancer Science and Therapeutics (ICST)

February 09, 2015


The endometrial cancer in Southern Tunisia: Investigation about 52 cases

Kebaili Sahbi Trigui K Louati D Charfi S Ben Hlima S Daoud J Chaabane K Amouri H

Research Article-Integrative Cancer Science and Therapeutics (ICST)

February 12, 2015

SERCA-as-a-target-for-cancer-therapies

Denise Casemore Chengguo Xing

Research Article-Integrative Cancer Science and Therapeutics (ICST)

February 26, 2015


An audit of inter-observer variability in Gleason grading of prostate cancer biopsies: The experience of central pathology review in the North West of England

Emile N Salmo

Research Article-Integrative Cancer Science and Therapeutics (ICST)

March 02, 2015


Quality of life among Brazilian women having undergone surgery for breast cancer: Validity and reliability of the Quality of life Questionnaire (EORTC QLQ-C30) and Breast Cancer Module (QLQ BR-23)

Ana Silvia Diniz Makluf Alexandre de Almeida Barra Rosângela Corrêa Dias Cristovão Pinheiro de Barros

Research Article-Integrative Cancer Science and Therapeutics (ICST)

March 08, 2015


Towards an integrated model of defense in gynecological cancer. Psychoneuroimmunological and psychological factors, between risk and protection in cancer: A review

Chiara Cosentino Carlo A. Pruneti

Research Article-Integrative Cancer Science and Therapeutics (ICST)

March 09, 2015


Effect of glycosylated vitamin D binding protein complexed with oleic acid on human myeloma and Hodgkin’s lymphoma cultures

Jacopo J.V. Branca Rodney J Smith Emma Ward Marco Ruggiero

Research Article-Integrative Cancer Science and Therapeutics (ICST)

March 17, 2015


Cytotoxicity of gemcitabine-loaded thermosensitive liposomes in pancreatic cancer cell lines

Kevin Affram Ofonime Udofot Edward Agyare

Research Article-Integrative Cancer Science and Therapeutics (ICST)

April 16, 2015


Retrospective review on: Local breast therapy in addition to systemic therapy in de-novo metastatic breast cancer

Tahani Nageeti Raid Jastania

Research Article-Integrative Cancer Science and Therapeutics (ICST)

May 02, 2015


Feasibility of liposuction for treatment of arm lymphedema from breast cancer: A prospective study and review of the literature

Erin Louise Doren Paul David Smith Weihong Sun MensuraLacevic William Fulp Rebecca Reid Christine Laronga

Research Article-Integrative Cancer Science and Therapeutics (ICST)

June 04, 2015


Rethinking NM23: An extracellular role for NDPKinase in breast cancer

Iain L. O. Buxton Senny Nordmeier

Review Article-Integrative Cancer Science and Therapeutics (ICST)

June 03, 2015


Antioxidants therapy: An alternative for androgen deprivation therapy (ADT) to decrease prostate-specific antigen (PSA) level

Mohammad Reza Naghii Mehdi Hedayati Mahmood Mofid

Research Article-Integrative Cancer Science and Therapeutics (ICST)

June 06, 2015


The cytogenetic and molecular analysis of chronic myeloid leukemia in a tertiary care hospital of Sindh, Pakistan

Ikramdin Ujjan Anwar Ali Akhund Abdul Mannan Baig Ghulam Shah Nizamani

Research Article-Integrative Cancer Science and Therapeutics (ICST)

June 17, 2015


Extrinsic targeting strategies against acute myeloid leukemic stem cells

Noureldien H. E. Darwish Shaker A. Mousa

Review Article-Integrative Cancer Science and Therapeutics (ICST)

June 22, 2015


Intrinsic targeting strategies against acute myeloid leukemic stem cells

Noureldien H. E. Darwish Shaker A. Mousa

Review Article-Integrative Cancer Science and Therapeutics (ICST)

June 22, 2015


Navigating commercial approval of therapeutics: The evolution of the United States Food and Drug Administration

Dillon Jarrell Megan Hamrick Michaela Good Anna Chopp Mark Brown

Commentry-Integrative Cancer Science and Therapeutics (ICST)

June 28, 2015


(+)-Aeroplysinin-1 inhibits Akt and Erk pathway signaling selectively in endothelial cells

Beatriz Martínez-Poveda Ana R. Quesada Miguel A. Medina

Research Article-Integrative Cancer Science and Therapeutics (ICST)

July 06, 2015


PKGI mediates the growth inhibitory effects of cGMP signaling in human breast cancer cells independent of β-catenin

Perrin F. Windham Paul S. Rodriguez Nicholas J. Rivers Heather N. Tinsley

Research Article-Integrative Cancer Science and Therapeutics (ICST)

July 22, 2015


Blockade of extracellular NM23 or its endothelial target slows breast cancer growth and metastasis

Nucharee Yokdang Senny Nordmeier Katie Speirs Heather R. Burkin Iain L. O. Buxton

Research Article-Integrative Cancer Science and Therapeutics (ICST)

August 04, 2015


The scopes and falls of molecular targeted therapy in gastric cancer

Vinod Vijay Subhash Wei Peng Yong

Review Article-Integrative Cancer Science and Therapeutics (ICST)

August 20, 2015


Single dose bevacizumab as treatment for symptomatic, corticosteroid-refractory pseudoprogression after chemoradiation therapy for newly diagnosed glioblastoma: A case report

Taylor M. Morris Isabelle Vallieres Andrew Attwell R Petter Tonseth Natella Jafarova David L. Saltman

Case Report-Integrative Cancer Science and Therapeutics (ICST)

August 24, 2015


Pituitary gland metastases from renal cell carcinoma: A case report and literature update

Domenico Murrone Francesco Amedeo Abbate Danilo De Paulis Renato Juan Galzio

Case Report-Integrative Cancer Science and Therapeutics (ICST)

August 27, 2015


Pleurodesis in malignant pleural effusions: Outcome and predictors of success

Hind Rafei Suha Jabak Alain Mina Arafat Tfayli

Research Article-Integrative Cancer Science and Therapeutics (ICST)

September 18, 2015


A case of unresectable small cell lung cancermore than 7 years of survival treated with cryoablation and low dose chemotherapy

Quanwang Li Tian Zhou Min Jiang Kaiwen Hu Franco Lugnani Antonio Cueto

Case Report-Integrative Cancer Science and Therapeutics (ICST)

September 19, 2015


Communicating with prostate cancer patients: Psychosocial profile and determinants of seeking psychosocial care

Laura Daeter Adriaan Visser Chantal van Harten Bert Voerman

Research Article-Integrative Cancer Science and Therapeutics (ICST)

September 21, 2015


Epiphrenic esophageal diverticulum within a leiomyoma: A rare cause of dysphagia

Omar Abdel-lah Fernández Alberto Alvarez Delgado Felipe Carlos Parreño Antonio Rodriguez

Case Report-Integrative Cancer Science and Therapeutics (ICST)

September 22, 2015


5-Fluorouracil-ınduced radiation recall dermatitis: A case report

Gonca Hanedan Uslu Emine Canyilmaz Savas Yayli Sevdegul Aydin Ahmet Yasar Zengin Adnan Yoney

Research Article-Integrative Cancer Science and Therapeutics (ICST)

September 25, 2015


BCL2L11 (BIM) deletion polymorphism, rather than BIM SNP, is an effective predictor of early molecular relapse after ABL tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia

Seiichiro Katagiri Tetsuzo Tauchi Kenichi Tadokoro Junko H. Ohyashiki Kazuma Ohyashiki

Letter to Editor-Integrative Cancer Science and Therapeutics (ICST)

September 28, 2015


Cytotoxicity of 5-fluorouracil-loaded pH-sensitive liposomal nanoparticles in colorectal cancer cell lines

Ofonime Udofot Kevin Affram Bridg’ette Israel Edward Agyare

Research Article-Integrative Cancer Science and Therapeutics (ICST)

October 09, 2015


Lysophosphatidic acid induces ME180 cell migration via its putative receptor GPR87

Ryo Saito Daisuke Furuta Shunsuke Nakajima Takuya Watanabe Shoichi Ochiai Takashi Fujita Norihisa Fujita

Research Article-Integrative Cancer Science and Therapeutics (ICST)

October 12, 2015


The unsuspected intrinsic property of melanin to transform light energy into chemical energy and the Warburg effect: Connotations in cancer biochemistry

Arturo Solis Herrera

Mini Review-Integrative Cancer Science and Therapeutics (ICST)

October 12, 2015


ABT-737 and Roscovitine induces apoptosis in a synergistic fashion in mast cells carrying the D816V KIT mutation

Katarina Lyberg Gunnar Nilsson Christine Möller Westerberg

Research Article-Integrative Cancer Science and Therapeutics (ICST)

October 16, 2015


Volume 1

Potential significance of the regucalcin gene in human carcinoma

Masayoshi Yamaguchi

Editorial-Integrative Cancer Science and Therapeutics (ICST)

Aug 01, 2014


The suppression of regucalcin gene expression may lead to hepatocarcinogenesis

Masayoshi Yamaguchi

Review Article-Integrative Cancer Science and Therapeutics (ICST)

Aug 03, 2014

Soluble CD30 and peripheral blood or pulmonary involvement of adult T-cell leukemia/lymphoma

Shigeki Takemoto Ratiorn Pornkuna

Short Communication-Integrative Cancer Science and Therapeutics (ICST)

October 02, 2014


Prognostic value of bone marker beta-crosslaps in patients with breast carcinoma

Nicole Zulauf Ingo Marzi Gerhard M Oremek

Research Article-Integrative Cancer Science and Therapeutics (ICST)

October 03, 2014


Disrupting cancer cell function by targeting mitochondria

Emily Ann Carlson Shirley ShiDu Yan

Research Article-Integrative Cancer Science and Therapeutics (ICST)

October 04, 2014


A new bidirectional intraperitoneal and systemic induction chemotherapy (BISIC) for the peritoneal metastasis from gastric cancer in neoadjuvant setting

Yonemura Y Canbay Endou Y Ishibashi H Mizumoto A Li Y Takeshita K Ichinose M Takao N Noguchi K Hirano M Glehen O Brűcher B Sugarbaker P

Research Article-Integrative Cancer Science and Therapeutics (ICST)

October 07, 2014


Assessing potential herb-drug interactions: A clinical decision-making guideline to mitigate patient risk

Shauna Birdsall Glen J Weiss

Review Article-Integrative Cancer Science and Therapeutics (ICST)

October 15, 2014

Tartrate-resistant acid phosphatase 5b as a diagnostic marker of bone metastases in patients with renal cell carcinoma

Robert Preussner Hildegund Sauer-Eppe Gerhard Maximilian Oremek

Research Article-Integrative Cancer Science and Therapeutics (ICST)

November 03, 2014


Cancer as a “mafia” within the body: A proposition of conceptual approach that seems congruent to the complex biology of the disease

Dariusz Adamek Anastazja Stoj

Letter to Editor-Integrative Cancer Science and Therapeutics (ICST)

November 09, 2014


Small molecule inhibitors as emerging cancer therapeutics

Lavanya V Mohamed Adil A.A Neesar Ahmed Arun K.Rishi Shazia Jamal

Review Article-Integrative Cancer Science and Therapeutics (ICST)

November 09, 2014


Weak burst-firing magnetic fields that produce analgesia equivalent to morphine do not initiate activation of proliferation pathways in human breast cells in culture

Nirosha J. Murugan Lukasz M M. Karbowski Michael A. Persinger

Research Article-Integrative Cancer Science and Therapeutics (ICST)

November 16, 2014


No association between TTTA short tandem repeat (STR) of the CYP19 gene and prostate cancer risk in Iranian population: A case control study

Kunihide Tanaka Farah Farzaneh Karimpur-zahmatkesh Jalil Hosseini Farkhondeh Pouresmaeili Abolfazl Movafagh Eznollah Azarghashb Mohammad Yaghoobi Reza Mirfakhraie

Research Article-Integrative Cancer Science and Therapeutics (ICST)

November 18, 2014


Topical administration of a newly devised anticancer agent: A novel concept of cancer chemotherapy

Akio Sugitachi Naoko Takahashi Kohei Kume Yukimi Ohmori Satoshi Nishizuka Yusuke Kimura Go Wakabayashi

Research Article-Integrative Cancer Science and Therapeutics (ICST)

December 15, 2014

Submit Manuscript


IOD welcomes direct submissions of manuscripts from authors. You can submit your manuscript to: submissions@oatext.com ; alternatively to: masayoshi@oatext.com

Publication Charges


Article Publication Charges (APC)

OA Text journals are open access, we do not charge the end user when accessing a manuscript or any article. This allows the scientific community to view, download, distribution of an article in any medium, provided that the original work is properly cited, under the term of"Creative Commons Attribution License". In line with other open access journals we provide a flat fee submission structure (dependent upon the journal) on the acceptance of a peer-reviewed article which covers in part the entirety of the publication pathway (the article processing charge). The process includes our maintenance, submission and peer review systems and international editing, publication and submission to global indexing and tracking organisations and archiving to allow instant access to the whole article and associated supplementary documents. We also have to ensure enough investment to secure a sustainable model which ethically, legally and financially stable.

1. What are your publication charges?

The costs of producing and maintaining OA Text are recovered by charging a publication fee to authors or research sponsors for each article that they publish.

Article type

Publication Fee (GBP / USD)

Research, reviews and other types of articles

£920 / $1300

Special issue articles

£690 / $890

2. Why are your charges set at these levels?

All articles published in OA Text are open access. Open Access publishing implies that all readers, anywhere in the world, are allowed unrestricted to full text of articles, immediately on publication in OA Text Journals. The Article Publication Charges pay for the editorial and production costs of the journal, for hosting the website, publishing articles online, preparing HTML , PDF and XML versions of the articles and submitting the articles in electronic citation database like CrossRef.

Our financial goals are to:

  • Recover capitalization costs;
  • Produce sufficient revenue to allow for a sustainable and scalable publishing program, under continuous development;
  • Bend the publication-charge cost downward over time.

3. When do I pay Article Publication Charges?

Article Publication Charges will have to be paid after the manuscript has been peer reviewed and accepted for publication. The corresponding author will be responsible for arranging the payments.

Special Issues


  • Lung Cancer

    Editor Affiliation:
    Kazuya Fukuoka, MD, PhD,
    Department of Medical Oncology
    Sakai Hospital, Kinki University Faculty of Medicine
    Japan

    Submission date: March 15, 2017
    Publication date: April 02, 2017

    Description of the Special Issue: The special issue focuses on all areas of lung cancer from basic biology to advanced treatment, prevention, epidemiology and etiology. Original articles, research, reviews, mini reviews, cases, commentaries, short communications, letters, opinions are accepted for publication.

    Submit manuscript to: editot.icst@oatext.com


  • Breast cancer

    Editor Affiliation:
    Masakazu Toi, M.D. Ph.D,
    Professor
    Breast Surgery, Kyoto University
    Japan

    Submission date: Feb 25, 2017
    Publication date: March 20, 2017

    Description of the Special Issue: The special issue is interested in all areas of biology and medicine related to breast cancer, including basic biology, genetics, causes, diagnosis, treatment etc., with focus on latest advances in breast cancer therapy. All types of articles are accepted for publication.

    Submit manuscript to: editot.icst@oatext.com


  • Brain tumor

    Editor Affiliation:
    Damir Nizamutdinov
    Associate Director of Neuro-Oncology Research
    Department of Neurosurgery
    Baylor Scott and White Health
    Assistant Professor of Surgery
    Texas A&M University
    USA


    Ekokobe Fonkem
    Neuro-Oncologist
    Baylor Scott & White Health
    USA

    Submission date: Feb 27, 2017
    Publication date: March 20, 2017

    Description of the Special Issue: The special issue accepts articles on all aspects related to the research in brain tumor and neuro oncology. Clinical and experimental results in tumor pathology, reviews, case reports on brain tumor, short communications, opinions, commentaries etc., are welcome for publication under this section.

    Submit manuscript to: editot.icst@oatext.com


  • Cancer Surgery

    Editor Affiliation:
    Johnson Miller Denise
    Director
    Hackensack Meridian Health
    NJ, USA

    Submission date: March 05, 2017
    Publication date: March 30, 2017

    The special issue focus on the surgical treatment of different cancer types like Breast Cancer, Lung Cancer, Kidney Cancer, Gastro intestinal cancer, gynaecological cancer, Thyroid Cancer, Prostate Cancer, neuro oncology, etc. All types of articles along with surgical images are suitable for publication.

    Submit manuscript to: editot.icst@oatext.com