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Frontiers in Drug, Chemistry and Clinical Research

Online ISSN: 2631-5424

Gian Maria Pacifici

University of Pisa, Italy

Ozgur KARCIOGLU

University of Health Sciences, Turkey

Frontiers in Drug, Chemistry and Clinical Research is a open access, peer-reviewed journal publishes publication of novel and innovative research from the areas of Pharmaceutical sciences and technology.

Journal will feature research, review papers, reports, editorials, expert opinion and perspective papers, commentaries, and book reviews.

Frontiers in Drug, Chemistry and Clinical Research direct submissions from authors: Attach your word file with e-mail and send it to: submissions@oatext.com

Please, follow the Instructions for Authors. In the cover letter add the name and e-mail address of 5 proposed reviewers (we can choose them or not).

Copyright is retained by the authors and articles can be freely used and distributed by others. Articles are distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published by Frontiers in Drug, Chemistry and Clinical Research, is properly cited.

Gian Maria Pacifici


Gian Maria Pacifici achieved the PhD in Biological Sciences at the University of Pisa, Pisa, Italy in 1971, and the PhD in Medical Sciences at the Karolinska Institutet, Stockholm, Sweden, in 1983.

Gian Maria Pacifici published 234 articles in peer scientific international journals. Gian Maria Pacifici received 11 international scholarships and worked in the following departments of clinical pharmacology: Laboratory of Clinical Pharmacology, Institute for Pharmacological Research, Mario Negri Milan, Italy, Department of Pharmacology, University of  Pisa, Pisa, Italy, Department of Clinical Pharmacology, Hammersmith Hospital, Royal Postgraduate Medical School, London, UK, Department of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge, Stockholm, Sweden, Department of Clinical Pharmacology, Uppsala University Hospital, Uppsala, Sweden, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK, Unit of Clinical Pharmacology, Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, UK, Unit of Clinical Pharmacology, Mayo Foundation, Rochester, Minnesota, USA and Department of Pharmacology, Arizona University, Tucson, Arizona, USA.

  • Gian Maria Pacifici is a member of the Editorial Board of 90 international journals, and a member of Editorial-in-chief of 5 journals.

  • Gian Maria Pacifici had been the Italian delegate at the European Commission, Brussels, Belgium, for the following Actions in the frame of Corporation in the Field of Scientific and Technical Research:

  • "Predicting and managing variability in the kinetics and effects of drugs during their discovery, development and use" (Action COST B1).

  • "Modelling in drug development" (Action COST B15).

  • “Physiologically based Pharmaco-toxicokinetics and dynamics” (Action COST B25).

Editing activities


  • Co-editor with Dr. G.N. Fracchia of the book: “Advances in Drug Metabolism in Man” published by the European Commission. DG XII - Science, Research and Development (EUR 154139 EN - ISBN 92-827-3982-1; 1995). This book is a text book of drug metabolism in man and was freely distributed by the European Commission to all Departments of Pharmacology and Clinical Pharmacology to the five continents.
  • Co-editor with Prof. Olavi Pelkonen, Professor of Pharmacology, University of Oulu, Finland, of the book: “Interindividual Variability in Human Drug Metabolism”. Taylor & Francis, London, UK (2001; ISBN 0-7484-0864-9; 2001).
  • Co-editor with Prof. Michel Coughtrie, Division of Pathology and Neuroscience, Ninewells Hospital and Medical, University of Dundee, Dundee, Scotland of the book: “Cytosolic Human Sulfotransferases”. Taylor & Francis-CRC, Boca Raton, FL, USA. (ISBN 0-415-28462-7, 2005).
  • Gian Maria Pacifici had been the coordinator of the Concerted Action entitled: “Identification of early factors in the variability of drug metabolism in man” in the frame of Biomed project. Contract BMH1 CT94-1622 (European Commission, Brussels, Belgium) in 1994-1997.

Ozgur Karcioglu, M.D.


I was born in Aydin, Turkey, in 1969. I was graduated from Ege University Medical School in 1993. In 1994, I started my residency in Dokuz Eylul University Medical School, Department of Emergency Medicine.

I conducted research on the “Role of end-tidal CO2 monitoring in patients intubated and resuscitated in the emergency department” as my thesis for specialty graduation in 1998.

I have been working as a faculty member since September 1998 in Dokuz Eylul University Medical School, Dept. of Emergency Medicine. I have gained docentship title in October, 2004. In the meantime, I completed the Fellowship Program in International Emergency Medicine Pennsylvania State University, Dept. of Emergency Medicine, Hershey, PA in June-August 2005. I have served as the chairman of the department in DEU between April 2005 and September 2007. I have been in charge of the ED of Istanbul Bakirkoy Research and Training Hospital for the Turkish Ministry of Health between 2007 and 2009. I have served as a faculty member in Acıbadem University Medical School, Dept. of Emergency Medicine between 2009-15. In the meantime (2011), I have also participated in the refreshment work for the Joint Commission International (JCI) certification in the Acibadem Bakirkoy Hospital.  At the end of 2015 I started serving in the Dept. of Emergency Medicine, Istanbul Education and Research Hospital, Fatih, Istanbul.

I have served as a founder and a board member of The Emergency Medical Association of Turkey between 2007 and 2009, and also member of The American College of Emergency Physicians, National Association of Trauma and Emergency Surgery, Association of Emergency Physicians, The European Society of Emergency Medicine-EuSEM. I have full command of spoken and written English.

121 articles of mine were published or accepted in international peer-reviewed journals and 61 in national ones. I have contributed in three books as editor, and authored fourteen chapters, besides three translation. I have given lectures and joined in educational activities in various symposia and seminars. I have also contributed in a total of 76 abstract presentations in scientific congresses and meetings. I’m serving as a member of The Editorial Board or associate editor of some Turkish journals as well as in The Turkish Journal of Trauma and Emergency Surgery, The World Clinics Journal of Medical Sciences and The World Clinics Journal of Pediatrics, WebMedCentral Emergency Medicine Speciality Editor (http://www.webmedcentral.com/wmc_editors), Emergency Medicine - Open Journal Editorial Board Member, Western Journal of Emergency Medicine (Reviewer), Human and Experimental Toxicology (Reviewer), Journal of Emergency Medicine and Intensive Care (Editorial Board Member), and International Scholarly Research Notices- Emergency Medicine (Editorial Board Member)  Journal of Clinical Toxicology (Editorial Board Member, 2018-), Journal of Vascular Diseases and Treatment  (Editorial Board Member, 2018-), World Journal of Surgery and Surgical Research (Editor-in-Chief, 2018- )

Twenty-two research projects have been conducted as specialty graduation thesis in our department under my supervision so far. I have also been serving as a member of the Commission for the Fifth- and sixth-year Medical Students’ Curriculum and the Committee for Active Medical Education. I have worked as the associate director of the eight-week training program of ‘Management of Trauma Victims’ embedded in “Task-based learning” sessions in fifth-year pre-graduate medical curriculum. I also serve as an instructor of the American Heart Association-based Basic and Advanced Cardiac Life Support Course. I was awarded with a “Fellowship of Emergency Medicine Association of Turkey” (FEMAT) in 2017.

My book projects entitled ‘Trauma Surgery’ and ‘Cardiac arrest and resuscitative procedures’ are going on currently with the collaboration of  the publisher InTechOpen.

My research interests are resuscitation, advanced life support, pain management, airway emergencies, disaster medicine, trauma and toxicology. 

Gian Maria Pacifici


Gian Maria Pacifici achieved the PhD in Biological Sciences at the University of Pisa, Pisa, Italy in 1971, and the PhD in Medical Sciences at the Karolinska Institutet, Stockholm, Sweden, in 1983.

Gian Maria Pacifici published 234 articles in peer scientific international journals. Gian Maria Pacifici received 11 international scholarships and worked in the following departments of clinical pharmacology: Laboratory of Clinical Pharmacology, Institute for Pharmacological Research, Mario Negri Milan, Italy, Department of Pharmacology, University of  Pisa, Pisa, Italy, Department of Clinical Pharmacology, Hammersmith Hospital, Royal Postgraduate Medical School, London, UK, Department of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge, Stockholm, Sweden, Department of Clinical Pharmacology, Uppsala University Hospital, Uppsala, Sweden, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK, Unit of Clinical Pharmacology, Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, UK, Unit of Clinical Pharmacology, Mayo Foundation, Rochester, Minnesota, USA and Department of Pharmacology, Arizona University, Tucson, Arizona, USA.

  • Gian Maria Pacifici is a member of the Editorial Board of 90 international journals, and a member of Editorial-in-chief of 5 journals.

  • Gian Maria Pacifici had been the Italian delegate at the European Commission, Brussels, Belgium, for the following Actions in the frame of Corporation in the Field of Scientific and Technical Research:

  • "Predicting and managing variability in the kinetics and effects of drugs during their discovery, development and use" (Action COST B1).

  • "Modelling in drug development" (Action COST B15).

  • “Physiologically based Pharmaco-toxicokinetics and dynamics” (Action COST B25).

Editing activities


  • Co-editor with Dr. G.N. Fracchia of the book: “Advances in Drug Metabolism in Man” published by the European Commission. DG XII - Science, Research and Development (EUR 154139 EN - ISBN 92-827-3982-1; 1995). This book is a text book of drug metabolism in man and was freely distributed by the European Commission to all Departments of Pharmacology and Clinical Pharmacology to the five continents.
  • Co-editor with Prof. Olavi Pelkonen, Professor of Pharmacology, University of Oulu, Finland, of the book: “Interindividual Variability in Human Drug Metabolism”. Taylor & Francis, London, UK (2001; ISBN 0-7484-0864-9; 2001).
  • Co-editor with Prof. Michel Coughtrie, Division of Pathology and Neuroscience, Ninewells Hospital and Medical, University of Dundee, Dundee, Scotland of the book: “Cytosolic Human Sulfotransferases”. Taylor & Francis-CRC, Boca Raton, FL, USA. (ISBN 0-415-28462-7, 2005).
  • Gian Maria Pacifici had been the coordinator of the Concerted Action entitled: “Identification of early factors in the variability of drug metabolism in man” in the frame of Biomed project. Contract BMH1 CT94-1622 (European Commission, Brussels, Belgium) in 1994-1997.

Ozgur Karcioglu, M.D.


I was born in Aydin, Turkey, in 1969. I was graduated from Ege University Medical School in 1993. In 1994, I started my residency in Dokuz Eylul University Medical School, Department of Emergency Medicine.

I conducted research on the “Role of end-tidal CO2 monitoring in patients intubated and resuscitated in the emergency department” as my thesis for specialty graduation in 1998.

I have been working as a faculty member since September 1998 in Dokuz Eylul University Medical School, Dept. of Emergency Medicine. I have gained docentship title in October, 2004. In the meantime, I completed the Fellowship Program in International Emergency Medicine Pennsylvania State University, Dept. of Emergency Medicine, Hershey, PA in June-August 2005. I have served as the chairman of the department in DEU between April 2005 and September 2007. I have been in charge of the ED of Istanbul Bakirkoy Research and Training Hospital for the Turkish Ministry of Health between 2007 and 2009. I have served as a faculty member in Acıbadem University Medical School, Dept. of Emergency Medicine between 2009-15. In the meantime (2011), I have also participated in the refreshment work for the Joint Commission International (JCI) certification in the Acibadem Bakirkoy Hospital.  At the end of 2015 I started serving in the Dept. of Emergency Medicine, Istanbul Education and Research Hospital, Fatih, Istanbul.

I have served as a founder and a board member of The Emergency Medical Association of Turkey between 2007 and 2009, and also member of The American College of Emergency Physicians, National Association of Trauma and Emergency Surgery, Association of Emergency Physicians, The European Society of Emergency Medicine-EuSEM. I have full command of spoken and written English.

121 articles of mine were published or accepted in international peer-reviewed journals and 61 in national ones. I have contributed in three books as editor, and authored fourteen chapters, besides three translation. I have given lectures and joined in educational activities in various symposia and seminars. I have also contributed in a total of 76 abstract presentations in scientific congresses and meetings. I’m serving as a member of The Editorial Board or associate editor of some Turkish journals as well as in The Turkish Journal of Trauma and Emergency Surgery, The World Clinics Journal of Medical Sciences and The World Clinics Journal of Pediatrics, WebMedCentral Emergency Medicine Speciality Editor (http://www.webmedcentral.com/wmc_editors), Emergency Medicine - Open Journal Editorial Board Member, Western Journal of Emergency Medicine (Reviewer), Human and Experimental Toxicology (Reviewer), Journal of Emergency Medicine and Intensive Care (Editorial Board Member), and International Scholarly Research Notices- Emergency Medicine (Editorial Board Member)  Journal of Clinical Toxicology (Editorial Board Member, 2018-), Journal of Vascular Diseases and Treatment  (Editorial Board Member, 2018-), World Journal of Surgery and Surgical Research (Editor-in-Chief, 2018- )

Twenty-two research projects have been conducted as specialty graduation thesis in our department under my supervision so far. I have also been serving as a member of the Commission for the Fifth- and sixth-year Medical Students’ Curriculum and the Committee for Active Medical Education. I have worked as the associate director of the eight-week training program of ‘Management of Trauma Victims’ embedded in “Task-based learning” sessions in fifth-year pre-graduate medical curriculum. I also serve as an instructor of the American Heart Association-based Basic and Advanced Cardiac Life Support Course. I was awarded with a “Fellowship of Emergency Medicine Association of Turkey” (FEMAT) in 2017.

My book projects entitled ‘Trauma Surgery’ and ‘Cardiac arrest and resuscitative procedures’ are going on currently with the collaboration of  the publisher InTechOpen.

My research interests are resuscitation, advanced life support, pain management, airway emergencies, disaster medicine, trauma and toxicology. 

Editorial Board

Elena Boggio

Department of Health Sciences
Università del Piemonte Orientale
Italy

Claudia Carbone

Department of Drug Sciences
University of Catania
Italy

D.K. Dhawan

Department of Biophysics
Panjab University
India


Ebtsam Mohmed Abdou

National Organization of Drug Control and Research
Egypt

Jiaur R. Gayen

Division of Pharmaceutics & Pharmacokinetics
CSIR - Central Drug Research Institute
India

Gülbin Firidin

Department of Environmental Sciences
Graduate School of Natural and Applied Sciences Gazi University
Turkey


Konstantina Soulele

Department of Pharmacy
School of Health Sciences
National and Kapodistrian University of Athens
Greece

Xiaodong Ma

College of Pharmacy
Dalian Medical University
P.R. China

Mugunthan Govindarajan

Emory Institute for Drug Development (EIDD)
Yerkes National Primate Research Center
USA


Mayada Ragab Farag

Forensic Medicine and Toxicology Department
Faculty of Veterinary Medicine
Zagazig University
Egypt

Todor Dudev

Faculty of Chemistry and Pharmacy
Sofia University
Bulgaria

Abdallah Florence

Centre de biophysique moléculaire
CNRS-University of Orleans
France


Achyut Adhikari

Assistant Professor
Central Department of Chemistry
Tribhuvan University
Nepal

Xiaodong Ma

College of Pharmacy
Dalian Medical University
China

Ahmed ma’mun abdel Aziz yossef

faculty 0f pharmacy
Cairo university
Egypt


Yannis E. Dimakopoulos

Assistant Professor in Transport Phenomena Laboratory of Fluid Mechanics & Rheology University of Patras
Greece

Dr. Gagandeep Singh Saggu

Postdoctoral Research Fellow Laboratory of Malaria and Vector Research National Institute of Health
USA

Mariana Fornazier Borges

Federal University of Uberlândia Center of Exact Sciences and Technology Institute of Chemistry Avenida Floriano Peixoto Uberlândia
Brazil


Prof. Dr. Guillermo Bracamonte

Assistant Professor
Institute of Physics and chemical Research of Cordoba
Argentine

Gian Maria Pacifici

Associate Professor
Biological Sciences
University of Pisa
Italy

Giuseppe Lanza

Assistant Professor of Neurology
KORE University of Enna Enna
Italy


Jong Cheol Rah

Director, Collaborative Research Project on Decision making Korea Brain Research Institute Daegu
Korea

Rosanna Avola

Master in Drug Regulatory Affairs
University of Catania
Enna
Italy

Bernadeta Lelonek-Kuleta

Assistant Professor The John Paul Catholic University of Lublin Chair of Public Health
Poland


Firman Zulkifli Amin

Consultant-Specialist Physician in Internal Medicine, Dermatology, and Stem Cell and Regenerative Medicine University of Tsukuba
Japan

Habib Yaribeygi

Chronic Kidney Diseases Research Center
Shahid Beheshti University of Medical Sciences Tehran
Iran

Khue Vu Nguyen

Departments of Medicine and Pediatrics University of California San Diego
USA


Aneta Ostrozka-Cieslik

Assistant Professor
Department of Pharmaceutical Technology School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec Medical University of Silesia in Katowice
Poland

Ankit Rochani

Research Fellow
Department of Pharmaceutical Science
Thomas Jefferson University
Philadelphia
USA

Patrizia Straccia

Department of Pathology and Surgery
Faculty of Medicine
Catholic University of Sacred Heart Rome
Italy

In press

Volume 1, Issue 3


Pentraxin 3, a novel inflammatory marker in heart failure patients: its expression in whole blood as a function of clinical severity

Cabiati M Salvadori C Verde A Del Ry S

Research Article-Frontiers in Drug, Chemistry and Clinical Research

September 20, 2018


Alternative therapeutic strategies to fight bacterial infections

Leila Mousavifar Rene Roy

Research Article-Frontiers in Drug, Chemistry and Clinical Research

October 17, 2018


Current Issue

Volume 1, Issue 2


Modeling health oriented lifelong learning (HOLL) to prevent, delay and/or treat aging or aged dementias caused by less mentally stimulating activities

Cheng K Cheng V Zou CH

Perspective-Frontiers in Drug, Chemistry and Clinical Research

August 6, 2018


Biomarkers for gastrointestinal immunotherapy-related adverse events

Shek D

Perspective-Frontiers in Drug, Chemistry and Clinical Research

August 9, 2018


Synthesis, vibrational characterization and antioxidant activity of newly synthesized indium(III) complex

Kostova I Atanasova V Todorov L Kondeva-Burdina M Tzankova V

Research Article-Frontiers in Drug, Chemistry and Clinical Research

August 13, 2018


Commentary: Synthetic Strigolactone analogues reveal anti-cancer activities on hepatocellular carcinoma cells

Razvi SS Hasan MN Moselhy SS Kumosani TA Al-Malki AL Kumosani AT Asami T

Commentary-Frontiers in Drug, Chemistry and Clinical Research

September 26, 2018


Synthesis of (E)-N'- (2-hydroxy-3, 5-dinitrobenzylidene) – 2 –cyanoa cetohydrazidederivatives as effective antimicrobial agents

Patil PS Toche RB

Research Article-Frontiers in Drug, Chemistry and Clinical Research

August 09, 2018


Archive


Volume 1
CC

Modeling health oriented lifelong learning (HOLL) to prevent, delay and/or treat aging or aged dementias caused by less mentally stimulating activities

Cheng K Cheng V Zou CH

Perspective-Frontiers in Drug, Chemistry and Clinical Research

August 6, 2018


Biomarkers for gastrointestinal immunotherapy-related adverse events

Shek D

Perspective-Frontiers in Drug, Chemistry and Clinical Research

August 9, 2018


Synthesis, vibrational characterization and antioxidant activity of newly synthesized indium(III) complex

Kostova I Atanasova V Todorov L Kondeva-Burdina M Tzankova V

Research Article-Frontiers in Drug, Chemistry and Clinical Research

August 13, 2018


Commentary: Synthetic Strigolactone analogues reveal anti-cancer activities on hepatocellular carcinoma cells

Razvi SS Hasan MN Moselhy SS Kumosani TA Al-Malki AL Kumosani AT Asami T

Commentary-Frontiers in Drug, Chemistry and Clinical Research

September 26, 2018


Synthesis of (E)-N'- (2-hydroxy-3, 5-dinitrobenzylidene) – 2 –cyanoa cetohydrazidederivatives as effective antimicrobial agents

Patil PS Toche RB

Research Article-Frontiers in Drug, Chemistry and Clinical Research

August 09, 2018


Design of advanced smart ultraluminescent multifunctional nanoplatforms for biophotonics and nanomedicine applications

Carina I. Salinas A. Guillermo Bracamonte

Research Article-Frontiers in Drug, Chemistry and Clinical Research

June 16, 2018


Can resistin be used as a biomarker in coronary artery disease: A review

Turgay Yıldırım Ö

Mini-Review-Frontiers in Drug, Chemistry and Clinical Research

June 19, 2018


The concept of the insulin intestinal uptake mechanism: Associated with polymeric nanoparticles

Rabiee N

Perspective Article-Frontiers in Drug, Chemistry and Clinical Research

July 25, 2018


Metallodrugs: Medicinal chemistry investigation

Rabiee N

Perspective Article-Frontiers in Drug, Chemistry and Clinical Research

July 27, 2018


Micro- nano vehicles: Self-propelling approach toward the Future

Rabiee N

Perspective Article-Frontiers in Drug, Chemistry and Clinical Research

July 27, 2018


Altered PU.1 activity in AML pathogenesis and new therapeutic interventions

Uz B

Perspective-Frontiers in Drug, Chemistry and Clinical Research

July 31, 2018


Submit Manuscript


Frontiers in Drug, Chemistry and Clinical Research direct submissions from authors: Attach your word file with e-mail and send it to: submissions@oatext.com

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