Take a look at the Recent articles

Simultaneous detection of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer nano drugs complexes

Alireza Heidari

Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA

American International Standards Institute, Irvine, CA 3800, USA

E-mail : bhuvaneswari.bibleraaj@uhsm.nhs.uk

Ricardo Gobato

Green Land Landscaping and Gardening, Seedling Growth Laboratory, 86130–000, Parana, Brazil

DOI: 10.15761/DOMR.1000370

Article
Article Info
Author Info
Figures & Data

Abstract

In the current work, simultaneous detection of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer Nano drugs complexes are studied. A technique that helps to achieve representative biopsies and that would enable accurate and early in vivo diagnosis is needed. This tool should detect lesions in pre–malignant/early stages and assess large tissue areas in real–time to decrease sampling errors. Several techniques have been tested for biopsy guidance, such as optical coherence tomography (OCT), white light reflectance (WLR), simultaneous detection of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer Nano drugs complexes.

Key words

simultaneous, detection, molecular paramagnetic relaxation, enhancements, DNA/RNA, gum cancer cells, anti–cancer nano drugs, complexes

Introduction

The high mortality rate of gum cancer can be reduced by early and accurate diagnosis, adequate surgical treatment, and by simultaneous detection of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer Nano drugs complexes. The reference standard for gum cancer diagnosis is histopathologic assessment of biopsies or diagnostic excisions of suspicious tissue. After biopsy/excision the tissue specimen is fixed, micro–sectioned and routinely stained with hematoxylin and eosin (H&E). The pathologist makes a diagnosis based on microscopic examination of the H&E stained section. Because only small portions of the lesional tissue is biopsied or excised for histopathological examination, there is the risk of sampling error and the pathology report remains a subjective assessment with simultaneous detection of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer Nano drugs complexes [1-10].

Results and discussion

This article reviews recent developments in the attempt to develop diagnostic techniques for gum cancers and precancers based on simultaneous detection of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer Nano drugs complexes. The article summarizes some facts about gum cancer biology as it pertains to simultaneous detection of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer Nano drugs complexes. It reviews certain instrumentation considerations and finally surveys the application of simultaneous detection of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer Nano drugs complexes for diagnosis on intact tissues. The article concludes with our perspective on the current status of simultaneous detection of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer Nano drugs complexes for clinical applications and its future (Figures 1 and 2).

Figure 1. Simultaneous detection of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer Nano drugs complexes

Figure 2. Modelling of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer Nano drugs complexes

Conclusion

Oncological applications of simultaneous detection of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer Nano drugs complexes have been contemplated, pursued, and developed at academic level for at least 25 years. Published studies aim to detect pre–malignant lesions, detect gum cancer in less invasive stages, reduce the number of unnecessary biopsies and guide surgery towards the complete removal of the tumor with adequate tumor resection margins. This review summarizes actual clinical needs in oncology that can be addressed by spontaneous simultaneous detection of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer Nano drugs complexes and it provides an overview over the results that have been published between 2010 and 2020. An analysis is made of the current status of translation of these results into clinical practice. Despite many promising results, most of the applications addressed in scientific studies are still far from clinical adoption and commercialization. The main hurdles are identified, which need to be overcome to ensure that in the near future we will see the first simultaneous detection of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer Nano drugs complexes–based solutions being used in routine oncologic diagnostic and surgical procedures.

Acknowledgments

This study was supported by the Cancer Research Institute (CRI) Project of Scientific Instrument and Equipment Development, the National Natural Science Foundation of the United Sates, the International Joint BioSpectroscopy Core Research Laboratory Program supported by the California South University (CSU), and the Key project supported by the American International Standards Institute (AISI), Irvine, California, USA.

References

  1. Heidari A, Brown C (2015) Study of composition and morphology of cadmium oxide (CdO) nanoparticles for eliminating cancer cells. J Nanomed Res 2(5): 20.
  2. Heidari A, Brown C (2015) Study of surface morphological, phytochemical and structural characteristics of rhodium (III) oxide (Rh2O3) nanoparticles. International Journal of Pharmacology, Phytochemistry and Ethnomedicine 1(1): 15-19.
  3. Heidari A (2016) An experimental biospectroscopic study on seminal plasma in determination of semen quality for evaluation of male infertility. Int J Adv Technol 7: e007.
  4. Heidari A (2016) Extraction and preconcentration of N–Tolyl–Sulfonyl–Phosphoramid–Saeure–Dichlorid as an anti–cancer drug from plants: a pharmacognosy study. J Pharmacogn Nat Prod 2: e103.
  5. Heidari A (2016) A thermodynamic study on hydration and dehydration of DNA and RNA−Amphiphile Complexes. J Bioeng Biomed Sci S: 006.
  6. Heidari A (2016) Computational studies on molecular structures and carbonyl and ketene groups’ effects of singlet and triplet energies of Azidoketene O=C=CH–NNN and Isocyanatoketene O=C=CH–N=C=O. J Appl Computat Math 5: e142.
  7. Heidari A (2016) Study of irradiations to enhance the induces the dissociation of hydrogen bonds between peptide chains and transition from helix structure to random coil structure using ATR–FTIR, Raman and 1HNMR Spectroscopies. J Biomol Res Ther 5: e146.
  8. Heidari A (2016) Future prospects of point fluorescence spectroscopy, fluorescence imaging and fluorescence endoscopy in photodynamic therapy (PDT) for cancer cells. J Bioanal Biomed 8: e135.
  9. Heidari A (2016) A bio–spectroscopic study of DNA density and color role as determining factor for absorbed irradiation in cancer cells. Adv Cancer Prev 1: e102.
  10. Heidari A (2016) Manufacturing process of solar cells using cadmium oxide (CdO) and rhodium (III) Oxide (Rh2O3) nanoparticles. J Biotechnol Biomater 6: e125.

Editorial Information

Founding Editor-in-Chief

Shigeru Watanabe
Meikai University Japan

Editor-in-Chief

Vagner Rodrigues
Federal University of Minas Gerais

Article Type

Research Article

Publication history

Received: October 02, 2020
Accepted: October 26, 2020
Published: October 30, 2020

Copyright

©2020 Heidari A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Citation

Heidari A, Gobato R (2020) Simultaneous detection of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer nano drugs complexes. Dent Oral Maxillofac Res 6: DOI: 10.15761/DOMR.1000370

Corresponding author

Alireza Heidari

Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604; American International Standards Institute, Irvine, CA 3800, USA

E-mail : bhuvaneswari.bibleraaj@uhsm.nhs.uk

Figure 1. Simultaneous detection of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer Nano drugs complexes

Figure 2. Modelling of intra– and inter–molecular paramagnetic relaxation enhancements in DNA/RNA of gum cancer cells–anti–cancer Nano drugs complexes