The prevalence of obesity worldwide is increasing and future projections predict that, by the year 2030, the number of obese people will exceed one billion individuals, that is, 15-20% of the world population. This pandemic is associated with multiple medical complications such as cardiovascular, metabolic, renal, psychological, neoplastic, musculoskeletal and respiratory disorders. The latter include obstructive sleep apnea (OSA), hypoventilation-obesity syndrome (OHS) and the asthma phenotype associated with obesity. This monograph covers these topics in a concise manner, highlighting the physiopathology, the clinical picture and the treatment. The fundamental objective is to dissect the interrelation between the mechanisms that operate in obesity to generate diverse respiratory entities and how to impact these mechanisms with therapeutic tools that allow prevent the appearance of these disorders. The vision that obesity is a multifactorial pathology where there are, environmental, genetic, immunological and inflammatory factors, is highlighted.
obesity, obstructive sleep apnea, obesity-hypoventilation syndrome, obesity-asthma phenotype
Obesity is considered a greater health risk. It is defined, in the simplest way, as a condition characterized by an excessive accumulation and deposit of body fat. In 1997 the World Health Organization (WHO) formally recognized obesity as a global pandemic. In 2015 it was estimated that 107.7 million children and 603.7 million adults were obese worldwide. The overall prevalence of obesity was 5.0% in children under 20 years and 12.9% among adults, predominantly in women for all ages and higher in people over 50 years. Overweight accounted for approximately 4 million deaths and 120 million disability-adjusted life-years (DALY). 70% of deaths related to a high body mass index (BMI) were cardiovascular and 60% of these deaths occurred in obese people . BMI (the index between body weight ([Kgs]/height [linear meters] to the second power) is the most practical, standard and widely used tool to define obesity. Obesity is quantified numerically when the BMI is >30 kg/m2. Among 25-30 is classified as overweight. In the United States (US) 40% of men and almost 30% of adult women are overweight and the prevalence of obesity is 36% in the USA, 24% in Canada and 26% in the United Kingdom (UK). Mortality seems to be associated with elevated BMI as an independent risk factor in these countries . BMI has become a risk factor for a group of chronic diseases in expansion that include cardiovascular, metabolic, musculoskeletal, neoplastic, psychological, renal, gallbladder and respiratory disorders [3-5].
Another significant fact is that not only has the prevalence of obesity increased in recent decades, but obesity also begins 10 years earlier than in previous, and therefore there is a longer period of induction of complications and mortality. Duration of 5-15 years of obesity doubles the risk of death from all causes, but greater than 15 years triples the risk. Duration of obesity is a risk factor for mortality and is independent of BMI . The longer duration of obesity exposes the patient to greater endogenous production of toxic oxygen radicals (ROS), which damage DNA and enzymes that metabolize carcinogens and alter the metabolism of endogenous hormones . There is a longer time to induce partial exhaustion of the β cells of the pancreas, causing insulinopenia with depression of glucose oxidation and impaired glucose tolerance. This leads to hypertension, dyslipidemia, increased serum glucose, which increases the risk of chronic diseases such as diabetes mellitus, cardiovascular diseases and cancer .
The respiratory system does not escape this growing expansion of chronic diseases associated with obesity. This work tries to update the interrelation between obesity and more well-known pathologies like OSA, OHS and others of more recent description like the asthmatic phenotype associated with obesity.
Obstructive Sleep Apnea (Osa)
OSA is a pathology characterized by recurrent collapse of the pharynx during sleep, partially (hypopnea) or total (apnea), thus producing a decrease or absence of airflow despite the respiratory efforts of the patient . The obstructive events (apneas and hypopneas) cause a progressive asphyxia, which as they increase, stimulate respiratory efforts against a collapsed airway, until the patient wakes up. These respiratory efforts related to awakening are known as RERA (respiratory event-related arousal). These episodes are associated with recurrent oxyhemoglobin desaturation . OSA is the most common type of sleep-disordered breathing (SDB). OSA is commonly associated with excessive daytime sleepiness, which is why it is also called obstructive sleep apnea syndrome or obstructive sleep apnea-hypopnea syndrome (OSAH). The cardinal symptoms of OSA include the "3 S's": Snoring, Sleepiness and Significant-other of sleep apnea episodes. These mnemonics has proven to be of value in teaching. There really is a continuum from simple snoring to OSA and intermediate to upper airway resistance syndrome (UARS). (Figure 1). Some authors consider the term UARS obsolete considering that it is included in the category of OSA, but conceptually it is a valid term. This continuum is known as sleep-related breathing disorders (SRBD). The value of this concept is that simple snoring is seen as the beginning of the problem, which associated with others medical conditions can evolve to UARS and if it is not treated will evolve to OSA. Untreated OSA can lead to death through cardiac, metabolic, traffic accident and other complications.
Figure 1. Interrelationship between SRDB and patient populations
Sleep-related disordered breathing continuum ranging from normal sleep to obstructive sleep apnea (OSA). Upper airway resistance syndrome (UARS) occupies an intermediate position between these extremes. Note areas of overlap among the conditions.
The America Academy of Sleep Medicine (AASM) defines apnea as the cessation of airflow with duration of 10 or more seconds with respiratory efforts. Hypopnea requires a reduction of airflow of at least 30% with respect to basal flow and RERA is an event that is characterized by a respiratory effort of at least 10 seconds that leads to waking the patient but does not meet the criteria of apnea or hypopnea. The quantification of these events requires a study during sleep (polysomnography=PSG) .
According to data from the Center for Diseases Control and Prevention (CDC) as early as 2013 the rate of sleep disorders reached epidemic proportions. In the US it affected 70 million people. It was estimated that 1 in 4 men and 1 in 10 women had OSA. This disease carries a high burden for society and health systems since it is associated with adverse events ranging from loss of productivity, increased risk of various diseases, to death . The prevalence of SDB increases with age, and the prevalence of OSA also seem to be increasing. The data from the Wisconsin Cohort Study indicate that the prevalence of OSA in patients between 30-60 years of age is 9-24% for men and 4-9% for women, increases with BMI and can reach 78% in patients with obesity morbid (BMI> 40) . The prevalence in children is less accurate, but many authors who work with sleep have the perception that SDB are increasing in this population to how obesity has increased in adolescents and many have similarities with the counterpart of OSA in adults, with the important exception that they can be sleepy or hyperactive. One study estimated that approximately 6% of adolescents may have SDB .
Generally, OSA symptoms are insidious and are present for years before the patient is referred for an evaluation. Usually the patient presents with a history of loud snoring and involuntary movement during sleep, excessive daytime sleepiness, frequent awakenings during sleep, with feelings of breathlessness or gasping, decreased concentration and altered cognitive functions during the day . Table 1 includes a list of nocturnal symptoms, Table 2 diurnal symptoms, Table 3 includes findings from the physical examination and Table 4 co-morbid conditions.
Table1. List of nocturnal symptoms
Nocturnal symptoms of OSA
Snoring, usually loud, habitual and bothersome to others
Witnesses apneas, which interrupt the snoring and end with a snort
Gasping and choking sensations the arouse the patient form sleep
Insomnia; with frequent arousals and involuntary movements during sleep
Table 2. Diurnal symptoms
Daytime symptoms of OSA
Nonrestorative sleep (the patient feels tired despite having “fallen asleep”)
Morning headache, dry or sore throat
Excessive daytime sleepiness
Cognitive deficit (intellect, memory, attention and execution)
Personality and mood changes (irritability, depression and anxiety)
Sexual dysfunction (impotence and decreased libido)
Table 3. Findings from the physical examination
Physical examination in OSA
Wide neck (>43 cm in men, and >37 cm in women
Retrognathia or micrognathia
High-arched hard palate
Table 4. Co-morbid conditions
Co-morbid conditions in OSA
Resistant arterial hypertension
Recurrent arterial fibrillation
Chronic heart failure
Pathobiologic Features and Risk Factors
The human upper airway is a unique structure with multiple purposes, involved in functions such as speech, mastication, swallowing solid and liquid foods and the passage of air. The anatomy and neural control of the upper airway has evolved to acquire these functions and is composed of 20 muscles and soft tissues but lacks rigid or bony support. Most notably, it contains a collapsible portion that extends from the hard palate to the larynx. Although the ability of the upper airway to temporarily change shape and momentarily close is essential for speech and swallowing during wakefulness, this feature also provides the opportunity for collapse at inopportunity times, such example as during sleep . Multiple methods, including the cross-sectional area of the upper airway by computed tomography (CT) and magnetic resonance (MRI) have shown reduced caliber of this route in patients with OSA compared with controls in the waking state. However, there are non-anatomical factors of the upper airway that are crucial for the appearance of the disorder during sleep . The transmural pressure is the difference between the pressure inside the airway (intraluminal pressure) and the external pressure exerted by the tissues that surround it. The higher the transmural pressure, greater the opening of the airway. As the transmural pressure decreases, the opening is smaller. Once a critical point has been reached (Critical pressure=Pcrit) to reduce this pressure, a displacement of the pharyngeal tissues into the airway collapses (Figure 2). As long as the transmural pressure does not exceed this Pcrit, the airway will persist obstructed, perpetuating the event (apneas/hypopneas). Measuring the Pcrit is a well-established technique for quantifying the collapsibility of the upper airway during sleep . On average, patients with OSA tend to have a critical pressure close to atmospheric pressure (O cm H2O of water) during sleep, but there is considerable variability among patients with OSA. The range fluctuates between -5 cmH2O to +5 cmH2O. A Pcrit equal to or close to +5 cmH2O indicates a highly collapsible airway, whereas if the Pcrit is sub-atmospheric it indicates a stable airway. The fact of keeping the upper airway dilated depends on the proper functioning of the dilator muscles. Among these, the most studied is the genioglossus muscle whose activity is diminished in patients with OSA . It should be noted that the measurement of Pcri is invaluable in OSA research, but the clinical use is very limited because the protocols are technically changing, invasive (CPAP masks and catheters to measure pharyngeal pressure), they consume time and require trained personnel to collect and analyze data .
Figure 2. Pcrit pivot role in pathogenesis of OSA
Upper airway collapsibility during sleep is represented by the critical pressure (Pcrit), which spans a range from health (negative) to disease (positive). Pcrit is determined by the mechanical loads imposed by boney structures and soft tissues on the pharynx, and are offset by neuromuscular responses to airway obstruction. Obesity can influence passive mechanical loads and neuromuscular control, thereby modulating upper airway collapsibility and sleep apnea susceptibility. The diminished central ventilatory stimuli contribute to this event
Anatomical factors such as enlarged tonsils, increased volume of the tongue, soft tissues or lateral walls of the pharynx (fat for example), increased soft palate length, abnormal positioning of the jaw or maxilla contribute to diminish the cross-sectional area of the upper airway and / or increase the pressure around it, which predispose to collapse . In adults it is very rare that the enlarged tonsils and adenoids are the cause of OSA and in this age group removing them is also rarely an effective surgical remedy; in children, 80% of those who have OSA heal with the removal of them .
Two non-anatomical factors are fundamental for the appearance of OSA; the reduced neuromuscular response of the upper airway to the central impulses and the instability of the central control. Neuromuscular activity of the upper airway, including reflex activity, decreases during sleep, and this reduction may be more marked in patients with OSA . This reduced response of the dilator muscles (which should be activated during sleep when the airway tends to collapse) is critical for initiating obstruction, particularly if there are anatomical reasons predisposing to collapse . For example, the genioglossus muscle receives central impulses from the brainstem but also reflex impulses of pharyngeal mechanoreceptors (basically negative pressure, sub-atmospheric or intra-luminal suction) and chemoreceptors. The loss of this reflex control contributes to the pathogenesis of OSA . An increased reflex response could protect obese individuals from the development of OSA, despite the anatomical compromise . Basically the dilator muscles must be activated and contracted to oppose the sub-atmospheric suction pressure in the pharynx during sleep and avoid collapse.
Instability of central control has also been described in patients with OSA during sleep. That is, in addition to an altered sensitivity and reduced activity of the dilator muscles of the upper airway, there is a reduction in ventilatory motor impulses during sleep. In fact, a mismatch has been described between the central neuronal impulses (loop gain) and the response of the dilator muscles . Thus, the combination of anatomical and non-anatomical compromise is crucial in preventing or promoting OSA. Another significant association is that between lung volume and permeability of the upper airway. When the pulmonary volume is reduced, there is a displacement of the diaphragm and thorax cephalad, which results in a loss of caudal traction in the upper airway favoring collapse .
In addition to structural and non-structural factors, in OSA a substantial degree of genetic control interacts with environmental factors. There is familial aggregation and racial predisposition that contribute to the development of the syndrome and the structural phenotype of the upper airway . Soft tissue traits of the upper airway, abnormalities of ventilatory control, respiratory response to resistive loading during sleep may have a genetic basis [27-30]. Studies of candidate genes have found in European Americans that C-reactive protein (CRP) and glial cell line-derived neutrophilic factor (GDNF) were associated with AHI as dichotomous and longitudinal trait and in African Americans variants of the 2A serotonin receptor. CRP seems to mediate inflammation in OSA. GDNF influences ventilatory control because it senses oxygen and CO2 in the transition to sleep, the response to hypoxia of the carotid body and the A5 nucleus of the ventrolateral pons, a critical area that regulates the generation of the respiratory pattern .
In OSA, oxidative stress and inflammation have been correlated. A gene encoding oxidative stress contributing to OSA has even been described. The gene could play a pivotal role by operating in a positive feedback loop causing OSA to begin with and then triggering an inflammatory response that obstructs the upper airway, exacerbating OSA . Metabolic syndrome is characterized by fasting hyperglycemia, systemic hypertension, dyslipidemia and obesity. There is evidence of oxidative stress and pro-inflammatory activity in this syndrome and also that OSA can contribute to its metabolic damage (Figure 3). Multiple studies have shown that patients with OSA have hyperglycemia of fasting and insulin resistance .
Figure 3. Relationship between OSA and the metabolic syndrome
OSA has been associated with 3 of the 5 major clinical abnormalities associated with the metabolic syndrome, which is hypertension, insulin resistance, and oxidative stress. OSA may be contributing to and/or modulating the severity of these metabolic abnormalities
To the extent that fat accumulates in fat reserves, adipokines (cytokines, chemokines, complement proteins and other acute phase reactants, plasminogen activator inhibitor I, eotaxin, VEGF and MCPI produced by adipose tissue) are secreted and released into the blood by influencing the function of the upper airway during sleep and exercising its pro-inflammatory activity. These factors regulate the distribution of body fat between the central (visceral) and peripheral (subcutaneous) compartments. Hypoxia of adipose tissue stimulates the infiltration of fat with macrophages that also release inflammatory mediators. Leptin and adiponectin are energy-regulating hormones . Leptin is a hormone that has to do with satiety, is elevated in obese patients and promotes inflammation. Adiponectin is an insulin-sensitizing hormone, has anti-inflammatory effects and is decreased in obese, favoring insulin resistance and inflammation. Obesity can induce an inflammatory state since adipose tissue is a source of pro-inflammatory cytokines such as TNF-α, IL-6, IL-18, IL-1B and leptin antagonists (SOBR=soluble leptin receptor) and PCR [35,36]. The fundamental point is to understand that obesity, OSA and metabolic syndrome have in common denominator an inflammatory phenomenon .
Two other events that have pathophysiological and therapeutic importance are apnea clusters and the respiratory threshold to arousal. Apneas during sleep occur in clusters and desaturation of hemoglobin occurs after each apnea, but is more marked after the first apnea than in the rest of the cluster. CPAP and oxygen together reduce desaturation to the extent that apneas may remain isolated . Awakening is not an essential event, as originally believed, for the reopening of the airway. There are patients with low threshold to wake up and others with high threshold. Frequent awakenings fragment sleep, which becomes unstable and prevents access to deep stages. Theoretically, strategies that reduce awakenings could allow a more stable breathing during sleep, reduce fragmented sleep and make it more restorative . For patients with the low threshold phenotype, the use of hypnotics is a common area of research. The patient and the drug must be exquisitely selected to increase the threshold but not reduce the activity of the respiratory muscles . However, in patients with high respiratory threshold for awakening, they are in danger, with hypnotics, of deepening and prolonging hypoxemia due to a dull breathing.
In addition to obesity, which is an obvious risk factor for OSA (but not all patients with OSA are obese) , there are two non-genetic risk factors: male gender and age. In the male gender OSA is more frequent than in the female gender, in a ratio of 2-3: 1 . Possibly this is due to the distribution of fat, as in the male gender there is a greater deposit of fat around the pharyngeal airway, and greater length of it which predisposes to collapse. Hormonal factors have also been invoked because the administration of testosterone in men with hypogonadism induces SDB. Post-menopausal women have OSA most frequently than pre-menopausal women . Women with hormone replacement therapy have a similar prevalence to pre-menopausal women. OSA is more frequent in patients older than 65 years. Greater deposition of fat and deterioration of the activity of the dilator muscles of the pharynx with age have been invoked as underlying mechanisms .
OSA is more frequent in the REM (rapid-eyes movements) phase of sleep than in the non-REM phase. The REM phase is associated with a decrease in the tone of the muscles of the upper airway, altering the ability of the dilator muscles (for example, the genioglossus) to exert a negative pressure outside the airway that pulls it, and also reducing the sensitivity of chemoreceptors. The relevance of surface tension of the upper airway in OSA and the impact of mechanical trauma and hypoxemia on prolonging and perpetuating the severity of OSA is not clearly known .
As early as 2014, the American College of Physicians recommended that every patient with daytime sleepiness should undergo a sleep study, preferably a PSG. The modalities available to identify the site of the obstruction include: lateral cephalometry, endoscopy, fluoroscopy, CT, MRI, and radiography. The respiratory function tests are not indicated for diagnosis or for the treatment plan in OSA alone. They may be indicated for patients with OSA who have co-morbid conditions that require testing. Routine laboratory studies at OSA are not helpful unless there are specific indications. Thyrotropin should be quantified if hypothyroidism is suspected. Cysteine has been described as a marker of OSA .
PSG is necessary for accurate diagnosis and evaluation of treatment. It must be done in a sleep laboratory accredited by the AASM, because it requires qualified technicians to attend the monitoring and specialized doctors to interpret the study. The stages of sleep are recorded by means of an EEG, electro-oculogram and an electromyogram (EMG) of the chin. The heart rate is monitored with a single-derivative EKG. Limb movements of the legs are collected via an anterior tibial EMG. Respiratory monitoring includes airflow of the nose and mouth (using thermal sensors and nasal pressure transducers), respiratory effort (using inductance plethysmography) and oxygen saturation of hemoglobin (pulse oximetry). Esophageal pressure monitoring was not performed in many sleep laboratories due to the invasive nature of the procedure. It serves to measure, indirectly, the resistance of the airway (UARS). The respiratory pattern is analyzed according to the definitions standardized by the AASM . Obstructive apnea is the cessation of airflow of at least 10 seconds with persistent respiratory efforts. Central apnea is the cessation of airflow of at least 10 seconds without respiratory efforts. A mixed apnea is an apnea that starts as a central apnea and ends as an obstructive apnea. The apnea-hypopnea index (AHI) is derived from the total number of apneas and hypopneas divided by the total sleep time. The normal value is controversial and many laboratories use about 5 events per hour. Arbitrarily the severity is a function of the number per hour. There of 5-15 mild, of 15-30 moderate and greater than 30, severe. Not necessarily the highest HAI correlates with the greater hypoxemia . RDI (respiratory disorders index) is an index that is sometimes used for decision making and refers to the number of events (they are not necessarily just apnea or hypopnea) that limit air flow and end in awakenings. It is not the same as there.
Patients with an RDI greater than 40 during the first 2 h of a PSG qualify at that time for a Split-night PSG, in which, the final phase of the study is used to titrate the continuous positive airway pressure and does not require a second conventional PSG to calibrate the CPAP device. In other words, the study is done and the CPAP is titrated in a single time. Diagnosis and treatment are made. If the RDI is 20-40, it can be considered Split-night PSG if the clinical observation shows prolonged obstructive events or marked desaturation of the oxygenation. A minimum of 3 hours of sleep is required to the titrated of the CPAP once the treatment with the same begins. If a single Split-night study does not allow adequate control of symptoms, a full-night CPAP titration is necessary . Repeat PSG is necessary if symptoms are not controlled with CPAP despite adequate adherence, to evaluate response to upper airway surgery, evaluate response to oral application therapy (OA), if a 15% increase occurs of previous weight and to assess the response to a REM suppressant medication if the symptoms persist.
Considerable controversy exists about the validity of the studies conducted with portable equipment in the home compared with those carried out in a sleep center with a PSG. From the available information, it is worth highlighting several facts. Home studies are not inferior to a PSG for the OSA study if the pre-test probability is high for OSA. Home studies do not measure sleep and therefore may underestimate the degree of apneas, leading to false negatives, particularly in patients with insomnia, or other coexisting sleep disorders, or with medical conditions that contraindicate the study (heart failure). However, if the results with the portable equipment are negative, the conventional PSG must be done . A new disposable patch placed on skin has been developed to detect apneas, with promising results [49,50].
A frequently used clinical diagnostic scale is STOP-BANG consisting of 8 data with yes or no answers (S=snoring, T=tired/sleepiness, O=observed apneas, P=arterial hypertension, B=BMI>25 Kg/m2, A=age, N=neck width> 40 cm, G=male gender). With a 0-2 score, moderate to severe apneas can be excluded. A score of 3 or more suggests apneas. The positive predictive value is low (31-47%) with a high rate of false positives. The sensitivity ranges from 92.9% (slight apneas) to 100% (severe apneas). It basically works to evaluate the severity of the apnea and define the need for a PSG .
The objectives of OSA treatment are basically two: to eliminate apneas and eliminate intermittent hypoxia and the complications that arise from it. As general measures it is recommended to sleep in lateral decubitus and although several positional therapies (PT) have been proposed, none is really superior to the others, the results are inferior to CPAP and the impact on the metabolic and / or cognitive component of the entity are unknown . You should not drink alcoholic beverages 4-6 hours before bedtime, and you should lose weight. A reduction of 10% of the weight leads to a reduction of 26% of RDI. The benefits of losing weight are several such as: lowering blood pressure, improving lung function and arterial blood gases, improving sleep structure, reducing snoring, awakening, and the level of optimal CPAP. The suspension of smoking and psychotropic drugs not prescribed by a professional should be encouraged.
The treatment of SRBD with CPAP first corrects OSA, then UARS, and finally snoring, and if the therapy is stopped prematurely, the symptoms recur. A problem with CPAP is that the adherence is unacceptably low . Although it is standard therapy and reduces morbidity and mortality, adherence is crucial not only for the management of OSA but also for other co-morbid conditions or complications. There are more than 100 CPAP masks to personalize the device but the chosen CPAP should cover nose (n CPAP) or nose-mouth (total-face CPAP) . Nasal CPAP is effective in OSA, mixed apneas and in some central apneas. It is a fan unit, which produces a positive pressure, of nasal application, which increases the caliber of the airway in the retro-palatine region and retro-gloss regions, acting as a pneumatic splint. The pressure applied to the airway must be higher than the Pcrit to avoid the collapse of the upper airway it must abolish the apneas / hypopneas, the desaturation of the hemoglobin, the snoring and the RERAs. The usual pressure ranges from 5-20 cm H2O [53,54].
Other potential benefits of CPAP are improvement in daytime sleepiness, high blood pressure, risk of stroke, heart disease (has positive effects on cardiac remodeling), and metabolic syndrome . It does not seem to have an effect on cognitive function. It also reduces costs and mortality . The improvement can be immediate or take up to 2 months to be noticed. If CPAP is discontinued early, restlessness and other OSA markers are reinitiated, usually in the first two weeks. Since the acceptance is poor (25% do not use it as indicated) , the equipment allows to monitor not only "the time in the machine" but "the time in the mask". It is recommended at least 4 hours/night/5-7 days although this recommendation is variable. The ideal is at least 7 hours per night and the tolerance of the first 3 months is critical for the continued use of CPAP. Education at various levels improves adherence. The experience of the technical team, and the close, regular and persistent follow-up, increase the use of the equipment. The complications that favor abandonment come from airflow and pressure. Suffocation, claustrophobia, difficulty in exhaling and sleeping, chest and musculoskeletal discomfort, aerophagia and sinus congestion are some the complaints. Less frequent are the pneumomediastinum, pneumothorax, pneumocephalus, tympanic rupture, skin abrasion, rash, conjunctivitis and nasal discomfort.
BIPAP is a modality that allows the inspiratory pressure of the expiratory to be adjusted independently. Also known as BILEVEL, positive expiratory pressure levels are adjusted to eliminate apneas and positive inspiratory pressure to eliminate hypopneas. The independent adjustment allows a decrease in airway pressure during the cycle, unlike conventional CPAP in which the pressure is continuous throughout the cycle. Therefore, the main indication is for patients who do not tolerate CPAP with high levels of pressure, patients with hypoventilation syndromes or associated COPD. It is much more expensive and has no clear advantages compared to conventional CPAP and neither is adherence much better . The technical improvements in equipment of last generation are evident. They weigh around 1.4 kg (3 lbs) and generate less than 4 dB of noise, which is less than that generated during a quiet conversation. The AASM suggests using BIPAP when the CPAP pressure exceeds 15 cmH2O . Automatic adjustment of the positive airway pressure (APAP), using an appropriate algorithm, can automatically increase or decrease the pressure based on the respiratory events identified. It is of particular help in patients who require the machine in the supine position rather than in the non-supine position and for patients with residual apneas greater than 10/hour after bariatric surgery . The short-term prognosis with positive pressure is good in many variables. The long-term prognosis is not known.
Oral application devices (OA) move the tongue forward or move the jaw and soft palate anteriorly, lengthening the posterior air space and dilating the airway. The minimum protrusion needed to be effective is 6-10 mm, and there are 3 basic designs with more than 40 devices on the market. The most used are MAS (mandibular advanced splint) and TRD (tongue-retaining devices) . AASM has published practical parameters and review of the use of OA in OSA . Basically OA is recommended in patients with mild-moderate OSA who do not tolerate CPAP or BIPAP. There is little benefit in severe OSA. It requires evaluation by a sleep specialist and a dental professional and a PSG that confirms efficacy. The goal is to reduce AHI to <5/hour, eliminate snoring and improve the sleep architecture. The ideal candidate is the patient with low BMI, young, with a small neck circumference, with normal pharynx and with positional OSA. CPAP is more effective than OA in reducing AHI by 5-10/hour. The adherence is not well defined but it seems to be low. Problems with the temporomandibular joint (occlusive changes), excessive salivation, discomfort in the face, misalignment and dental displacement, changes in the bite, myofascial pain, chewing sounds and tongue pain are some of the causes of inefficiency and no adhesion . The price of equipment ranges from $300-2,500.
Electrical stimuli of the upper airway applied through an electrode that is implanted in the hypoglossal nerve and a device that is implanted in the skin of the thorax have been proposed for patients who can’t tolerate CPAP. Although it is true that some indicators of upper airway obstruction such as AHI, sleep structure, hypoxemia and the Epworth scale can improved  and Woodson and colleagues have shown efficacy and subjective benefit at 18 months of their use , its long-term benefits are not clear and a third of patients do not respond . ProventR is a one-way valve that maintains a constant pressure in the pharynx, without requiring tube or electricity .
Surgical treatment in OSA is defined in two levels: surgery for weight reduction and upper airway surgery. Obesity is a major risk factor for OSA and 70% of patients with OSA are obese, and there is a well-documented correlation between BMI and AHI, therefore all patients should be encouraged to lose weight . Unfortunately many diet programs to lose weight fail, because other OSA determines metabolic changes that prevent weight loss. In patients with severe obesity (BMI>40), bariatric surgery, including gastric bypass and bandage, is a modality of weight reduction when the conventional method fails . Both alternatives may have beneficial effects in OSA, although the surgical alternative offers a greater and significant improvement over the non-surgical one .
The role of surgery in upper airway management in OSA remains extremely controversial and the reason why it is not a standard approach is the absence of long-term studies that show that it continues to be effective 5 years or more after it has been performed. The goal of the surgery is to remove the cause of the obstruction and expand the airway . The most frequent sites of obstruction are the oropharyngeal tract (collapse of retro-gloss and retro-palatine regions due to macroglossia, low soft palate, or enlarged tonsils) and the nose (congestion, polyposis, and chronic rhinitis) . Nor should it be conceptualized as a "last ditch" attempt since it may be the correct alternative if OSA is minimal (RDI<20) and oxygen saturation of hemoglobin >90%, medical therapy is rejected and the patient is stable for a surgical procedure, or if CPAP fails, or if there are specific abnormalities that cause OSA (3 of 200 patients with OSA have space-occupying lesions that cause the obstruction). Many patients have non-correctable space-occupying injuries .
Obstruction in patients with SDB is classified anatomically into 3 types according to the region involved. Type I only involves the retro-palatine region, III the retro-gloss region and II both. Uvulopalatopharyngoplasty (UPPP) corrects type I obstruction. UPPP resects the uvula, soft palate, tonsils and redundant pharyngeal tissue. It is effective only in 40% of patients and the symptoms recur if the patient gains weight. In addition, side effects appear in 20-30% of patients (veil-palatal insufficiency, dry throat and problems with swallowing). The genioglossus advancement with hyoid myotomy (GAHM) can correct the type III obstruction and the maxillomandibular osteotomy (MMO) corrects the obstruction at both levels. There are really no good studies that evaluate the success of craniofacial reconstructions. In adults, the nose infrequently has an impact on sleep apnea . Tonsillectomy and adenoidectomy are the surgical procedures to treat OSA in children and are highly effective . The UPPP can be conventional or assisted with lasser (LAPP). Radiofrequency ablation of the palate (RFA) is a less invasive alternative than UPPP and consists of generating a scar on the soft palate to generate stiffness . But again, there is an absence of good evidence of effectiveness. The fundamental problem with these procedures is that the effectiveness decreases with age and weight gain and this is a determining factor in the recurrence of OSA after surgery.
Tracheostomy provides definitive correction because "bypasses" the obstruction. It is indicated for severe OSA that does not tolerate CPAP or that has cor-pulmonale. It is 100% effective, but it is disfiguring and drastically decreases the quality of life.
The application of negative oral pressure as an alternative to positive pressure awaits future research into a technology that is evolving.
To date, pharmacological attempts to increase upper airway activity have not been particularly successful and are not recommended as primary OSA therapy [71,72]. The antidepressant, desipramine, can reduce the collapsibility of the upper airway, increasing the response of pharyngeal muscles to obstruction during sleep . The hypnotic Zolpidem (acts on the adrenergic GABA system) also increases the response of the pharyngeal muscles during sleep . Residual somnolence despite effective treatment with CPAP occurs at 5%. Sometimes because with the initial improvement there is a tendency to underutilize CPAP a posteriori, alcohol use, changes in medication or use of sildenafil. It should be remembered that the latter inhibits cGMP phosphodiesterase by prolonging the action of cGMP and NO which promotes congestion of the upper airway, muscle relaxation and pulmonary vasodilation exacerbating OSA . If a clear cause of the phenomenon is not found and the level of CPAP is optimal, modafinil or armodafinil (approved by the FDA for this indication) can be added at a dose of 100-200 mg VO for fatigue or 400 mg to induce sleep . Acetazolamide, medroxyprogesterone, fluoxetine, protriptyline, metil-xanthines and estrogens are not recommended. In the pediatric population, subjected to tonsillectomy due to OSA, opioids should be used with care, preferring acetaminophen / ibuprofen as analgesics in the postoperative period .
To summarize the treatment, to all patients should be offered CPAP. If OSA is minimal-moderate and rejects n CPAP, BIPAP can be offered. If it fails or is rejected, it can be turned to OA. OA could be considered primary therapy if OSA is minimal and rejects CPAP. All available tools should be used to induce use and improve CPAP tolerance. The use of surgery or pharmacological treatment should be left to a sleep disorder specialist and a center with experience in the procedures.
Complications and mortality
OSA severe, untreated, has a higher risk of cardiovascular mortality, basically myocardial infarction and stroke, and although controversial, the risk seems to be reduced with the use of CPAP [77-79]. Patients with OSA have twice the prevalence of coronary artery disease and 2-4 times more risk of complex arrhythmias (bradyarrhythmias, AV block, premature ventricular contractions) and atrial fibrillation . The risk of atherosclerosis increases with OSA by exacerbating atherogenic factors such as systemic hypertension, insulin resistance, diabetes mellitus, dyslipidemia, and systemic inflammation. CPAP can attenuate this effect . CPAP reduces the activity of the renin-angiotensin system associated with decreased glomerular filtration and increased renal plasma flow, reduces plasma aldosterone and proteinuria. The connection between OSA and chronic kidney disease is generated by hyperfiltration induced by hypoxia . The Sleep Hearth Health Study showed that OSA has a strong association with stroke, greater than any other cardiovascular disease . Repeated acute cardiovascular stress due to occlusion of the upper airway generates hypoxemia, re-oxygenation (ROS), cyclic changes in intrathoracic pressure, and fragmented sleep. All these mechanisms are responsible for hypertension of the pulmonary artery in OSA .
OSA is associated with an increase of 2.5 times the risk of traffic accidents .
COPD affects 10% of the adult population, older than 40 years. SAHS affects 5% of the same population. The coexistence of both occurs at 0.25% and is known as overlap syndrome. Actually the prevalence of SAHS is not higher in patients with COPD than in the general population and the occurrence of both is a statistical association but there is no pathophysiological connection between the two entities. In this type of patients, dyspnea is greater than expected for the degree of bronchial obstruction, its functional compromise is greater and the optimized treatment of both pathologies improves survival . Patients with childhood onset asthma have an increased risk of subsequent OSA. The risk is double in this population with respect to asthma starting in adult life . OSA has been described associated with idiopathic pulmonary fibrosis .
OSA and epilepsy are particularly associated in older adults with recent-onset epilepsy, and seizure control improves with treatment, not only anticonvulsants, but also co-existing OSA . Studies in animals and "in vitro" have shown that intermittent and chronic hypoxia promotes tumor growth and resistance to radiotherapy. The data analysis of the Wisconsin Sleep Cohort Study demonstrated an association between cancer mortality and severity of OSA and hypoxemia. The association between tissue hypoxia and cancer can be explained by the increased hypoxia-induced angiogenesis since the activation of inducible hypoxia factor (HIF-1α) stimulates vascular endothelial growth factor (VEGF) in tumor cells .
Obesity Hypoventilation Syndrome (Ohs)
Alveolar hypoventilation can be caused by several disorders that are collectively classified as hypoventilation syndromes. Patients with alveolar hypoventilation have ventilatory failure leading to hypercapnia, that is, an increase in pCO2. They can also develop hypoxemia that aggravates clinical manifestations. Causes of alveolar hypoventilation include: central alveolar hypoventilation, deformities of the chest wall, neuromuscular disorders, COPD and OHS which is the subject that is discussed below .
Patients with OHS have abnormal ventilatory control and obesity, both contributing to the development of the syndrome. It is defined as such, the combination of obesity (BMI> 30 Kg/m2) and chronic hypercapnia (pCO2>45 mm Hg or >5.98 Kp) in absence of other pathologies that cause hypoventilation (neuromuscular, metabolic, pulmonary or chest wall). 90% of patients with OHS have OSA . This hypoventilation worsens during REM as does OSA. These patients have a high incidence of restrictive disorders in pulmonary function tests, excessive respiratory work, increased CO2 production and reduced pulmonary compliance when compared with obese patients without the syndrome . Leptin deficiency or resistance to it can contribute because the deficit of the hormone reduces the ventilatory response and promotes CO2 retention. Obese mice, genetically altered, with leptin deficiency are phenotypically similar to patients with OHS. The replacement of leptin in mice reverses chronic hypercapnia suggesting a possible role in the pathogenesis of OHS. The most important factor for the onset of the syndrome is an effect on central respiratory control with a reduced response to hypercapnia, hypoxia or both .
The prevalence of OHS in the adult population rangers between 0.15-0.30% . Data from the CDC show that with the increase in obesity the prevalence of OHS will increase . It is more common in men than in women in a ratio of 2:1 and usually in people older than 50 years . HTAP is more common and more severe in patients with OHS than with OSA alone and patients with OHS have higher admission rates in CCU than obese patients without hypoventilation .
The clinical manifestations of hypoventilation syndromes are nonspecific, and depend mainly on hypoventilation and the development of hypercapnia and hypoxemia. At the beginning, patients are asymptomatic or with minimal symptoms, such as dyspnea of exercise and as it progresses, cyanosis, delirium, confusion, drowsiness and obtundation due to hypoxemia and CO2 narcosis appear. Asterixis, myoclonus, seizures and papilledema may appear, as well as dilation of facial and conjunctival vessels . Patients with OHS may have OSA symptoms such as hyper-drowsiness, fatigue, loud snoring, nighttime asphyxia, and morning headaches. They may also have pulmonary hypertension with right heart failure and peripheral edema in advanced disease (Pickwickian syndrome). At the physical examination, in addition to the obvious obesity, cor-pulmonale data will appear. Arterial gases to evaluate hypoxemia and acid-base status, blood count (polycythemia), EKG (right ventricular hypertrophy and right atrial growth), chest x-ray (heart failure), echocardiogram (pulmonary artery pressure and right ventricular growth) and respiratory function tests (document restriction severity) are part of the diagnostic work in OHS. The total percentage of sleep with SpO2 <90% can be a polysomnographic variable of help to evaluate patients with OHS .
OHS is associated with a high rate of morbidity and mortality. The goal of management is to normalize pCO2, reduce the desaturation of oxyhemoglobin and improve symptoms. Non-invasive positive airway pressure therapy is typically the first-line treatment for OHS . This modality significantly reduces the nocturnal pCO2 increase and improvers sleepiness during the daytime. The alternatives for this modality are CPAP, BiPAP and other NIV modalities (non-invasive ventilation). CPAP is recommended if SRBD coexists and NIV if the patient has hypercapnia in the absence of apneas or hypopneas. BiPAP is the choice if there is nocturnal desaturation of oxyhemoglobin or nocturnal increase in pCO2. NIV and CPAP significantly improve the polysomnographic and respiratory parameters compared with other modalities such as lifestyle modification . 50% of patients with OHS, with positive pressure, also require oxygen therapy. Only oxygen for OHS is an inadequate strategy. Weight loss significantly improves OHS symptoms by reducing CO2 production, the severity of sleep apnea and alveolar ventilation. It also reduces pulmonary hypertension and left ventricular dysfunction, which improves cardiovascular compromise in OHS. The fundamental problem in the modern world is to keep the weight stable. Bariatric surgery with its different alternatives (produce gastric restriction or malabsorption) should be considered for refractory cases since operative mortality is high in OHS. Tracheostomy relieves airway obstruction during sleep, improves alveolar ventilation and pCO2 during wakefulness, but some patients do not return to the eucapnic state and do not change CO2 production. Sodium bicarbonate should not be infused because the central nervous system is alkalinized, which can cause seizures and the consequent metabolic alkalemia can generate cardiac dysrhythmias. Acetazolamide and medroxyprogesterone can potentially reverse hypercapnia but its routine use is not recommended due to the narrow margin between safety and long-term side effects. Leptin replacement therapy has shown relief of nocturnal hypoventilation and obstruction of the airway during sleep secondary to increased upper airway respiratory stimulus and diaphragm in experimental studies with mice, but its use in humans is not recommended .
OHS is associated with reduced quality of life and prolonged admission and time rates in intensive care units. In patients with associated comorbidities such as diabetes mellitus and bronchial asthma, mortality is significantly high, greater than 23% at 18 months and 46% at 50 months. Early use of CPAP can reduce the associated mortality to 10% [99,100].
Asthma and Obesity
Bronchial asthma is the most common chronic inflammatory disease in children and adults. It affects approximately 315 million people in the world, with a prevalence of 1-16% and it is estimated that it causes 346,000 deaths each year .
The prevalence of asthma is increasing in obese patients, particularly in women with abdominal obesity [103,104]. Weight reduction may decrease the incidence of asthma. There is, with weight reduction, an improvement in lung function and symptoms, but not of obstruction or bronchial hyperreactivity.
Patients with severe asthma constitute 3-10% of the asthmatic population in adults with asthma, but consume more than 60% of the costs of the disease, basically by medication. These costs are higher than the costs for diabetes mellitus type 2, stroke and COPD . From the point of view of inflammatory profile, there are two asthmatic phenotypes. In persistent type 2 inflammation, patients produce Th2 cytokines (IL-4, IL-5, IL-13) which promote the production of IgE and eosinophils. In the paucigranulocytic inflammatory pattern there is little inflammation of the airways and bronchial obstruction presumably occurs by other mechanisms. Within the first phenotype there is a cluster of obese patients. Moore and colleagues have identified several clinical phenotypes within the group of severe asthmatics. The phenotype associated with obesity (type 3) is characterized by being mainly older women, obese, with late onset asthma, with moderate reduction in FEV1 and frequent use of health resources, which require oral steroids for the management of exacerbations and with eosinophilic airway inflammation . Generally, the obstruction is mild compared to symptoms that are disproportionate to the alteration of lung function. Persistent eosinophilia of airways while receiving high doses of inhaled steroids suggests insensitivity to steroids and/or systemic effects of obesity . From the perspective of childhood asthma the relationship with obesity had not been clear either. Chen and colleagues found in their work that early-onset asthma increases the risk of obesity in children. Interestingly, the use of rescue bronchodilators (and no other medication) reduced the risk by half . Β2-agonists can protect against obesity since fat cells have receptors for β-agonists and their stimulation produces lipolysis .
The information in the literature allows postulate several mechanisms or points of union between asthma and obesity. Obesity increases the prevalence of asthma and reduces control. In obesity the tidal volume and the residual functional capacity are diminished, which promotes airway obstruction. Obesity induces a low-grade inflammatory state that can impact the airway to exacerbate asthma. Changes in hormones derived from adipose tissue such as leptin and adiponectin can participate in these events. Comorbidities associated with obesity such as dyslipidemia, GERD, SDB. DM or HTA can make asthma worse [110,111]. Genetic, hormonal and neurogenic influences have also been invoked .
Obesity is a current pest in which genetic, racial and possibly other factors are involved, but the environmental factor is the main one due to the bad eating habits of the modern world.
With few exceptions, no population of the planet escapes its impact.
This pathology has a deep metabolic, immunological and inflammatory background disorder that encompasses various organs and systems of the human economy ranging from cardiovascular diseases to cancer.
The respiratory system does not escape this expanding spectrum of various diseases and includes OSA, OHS, overlap syndrome between COPD and OSA, and asthma associated with obesity.
Although it is true that each of them has an associated pathogenic component such as inadequate central ventilatory control, or imbalances between the central impulses and the response of muscles of the upper airway, or an inflammatory profile of their own, obesity is a determining factor in the expression of syndromes
Therefore, although the investigations of the alternative pathogenic mechanisms are important, research in obesity and particularly in prevention is vital, since to the extent that weight control is achieved, the health intervention of the various diseases associated with obesity, can be reduced and better controlled by decreasing morbidity and mortality rates and the costs of health systems.
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