Department of Hematology and Medical Oncology, Emory University School of Medicine, 1365 C Clifton Road, NE, Atlanta, GA 30322, USA
E-mail :yamamasa1155@yahoo.co.jp
DOI: 10.15761/IMM.1000102
2021 Copyright OAT. All rights reserv.gif)
Figure 1. Role of regucalcin (RGN) in the regulation of lipid metabolism and implication with obesity and diabetes. RGN stimulates differentiation from bone marrow mesenchymal (BMM) stem cells to adipocytes, and it enhances adipogenesis and enhances triglyceride in the adipocytes. RGN suppresses leptin expression in adipocytes that regulate feeding. RGN stimulates glycolysis and production of in the liver cells, and it suppress adiponectin and leptin mRNA expression in the liver cells.
