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Fluvastatin decreasing interleukin-8 production may be used to reduce cardiovascular risk in patients with Behcet’s disease

Yinfang W

Department of Hepatobiliary and Pancreatic Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, PR China

Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Hangzhou 310014, Zhejiang Province, PR China

The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang Province, PR China

E-mail : bhuvaneswari.bibleraaj@uhsm.nhs.uk

Xiaodong S

Department of Hepatobiliary and Pancreatic Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, PR China

Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Hangzhou 310014, Zhejiang Province, PR China

The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang Province, PR China

DOI: 10.15761/CMI.1000146

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Key words

Behcet’s disease, Fluvastatin, Interleukin-8, Cardiovascular risk

Behcet’s disease (BD) frequently occurs in our daily clinical work. BD patients usually need intensive care in the late-stage of the disease because of frequently occurred cardiovascular events [1-3]. However, potential medical interventions to patients with BD still remain unclear. Here, we speculate that fluvastatin decreasing interleukin-8 (IL-8) production could be used to reduce the cardiovascular risk in BD patients.

BD is characterized by a multi-systemic inflammatory disorder. Previous studies showed serum IL-8 levels were significantly elevated in BD patients [4]. Furthermore, there is sufficient evidence to support that IL-8 was involved in the establishment and preservation of the vessel wall inflammation within numerous cardiovascular disease, such as atherosclerosis and myocardial infarction [5], showing a novel intervention target for BD. Importantly, fluvastatin, a HMG CoA reductase inhibitor, has been firmly identified to decrease IL-8 production in whole blood6 and human vascular smooth muscle cells [6,7], suggesting its potential intervention role in cardiovascular risk in BD patients. Moreover, in addition to the possible way through regulation of IL-8,fluvastatin has been widely confirmed to achieve a remarkable therapeutic effect on cardiovascular disease by modulating lipid metabolism.

In conclusion, fluvastatin may reverse the up-regulation of serum IL-8 levels in BD. If so, reasonable application of fluvastatin as a conventional medication presents a potential therapeutic approach for treating IL-8-induced cardiovascular morbidity and mortality in BD patients.

Conflicts of interest

There are no conflicts of interest associated with this manuscript.

References

  1. Wu XY, Wei JP, Zhao XY, Wang Y, Wu HH, et al. (2015) Spontaneous Intra-Abdominal Hemorrhage Due to Rupture of Jejunal Artery Aneurysm in Behcet Disease: Case Report and Literature Review. Medicine (Baltimore) 94: e1979. [Crossref]
  2. Yavne Y, Tiosano S, Watad A, Comaneshter D, Cohen AD, et al. (2017) Investigating the link between ischemic heart disease and Behcet's disease: A cross-sectional analysis. Int J Cardiol 241: 41-45. [Crossref]
  3. Rico JV, Pedrajas FG, González IC, Iglesias RJ (2011) Urgent endovascular treatment of a ruptured tibioperoneal pseudoaneurysm in Behçet’s disease. Ann Vasc Surg 25: 385. e11-385. e14.
  4. Kartal Durmazlar SP, Ulkar GB, Eskioglu F, Tatlican S, Mert A, et al. (2009) Significance of serum interleukin-8 levels in patients with Behcet's disease: high levels may indicate vascular involvement. Int J Dermatol 48: 259-264.
  5. Apostolakis S, Vogiatzi K, Amanatidou V, Spandidos DA (2009) Interleukin 8 and cardiovascular disease. Cardiovasc Res 84: 353-360. [Crossref]
  6. Jouneau S, Bonizec M, Belleguic C, Desrues B, Brinchault G, et al. (2011) Anti-inflammatory effect of fluvastatin on IL-8 production induced by Pseudomonas aeruginosa and Aspergillus fumigatus antigens in cystic fibrosis. PLoS ONE 6: e22655.
  7. Ito T, Ikeda U, Yamamoto K, Shimada K (2002) Regulation of interleukin-8 expression by HMG-CoA reductase inhibitors in human vascular smooth muscle cells. Atherosclerosis 165: 51-55.

Editorial Information

Editor-in-Chief

Dr. Ume Wollina

Article Type

Short Communication

Publication history

Received date: October 20, 2017
Accepted date: November 13, 2017
Published date: November 17, 2017

Copyright

© 2017 Yinfang W. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Citation

Yinfang W (2017) Fluvastatin decreasing interleukin-8 production may be used to reducecardiovascular risk in patients with Behcet’s disease. Clin Med Invest 2: DOI: 10.15761/CMI.1000146

Corresponding author

Xiaodong Sun

Department of Hepatobiliary and Pancreatic Surgery, Zhejiang Provincial People’s Hospital, No. 158 Shangtang Road, Hangzhou 310000, Zhejiang Province, PR China.

E-mail : bhuvaneswari.bibleraaj@uhsm.nhs.uk

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