Follow us on :


Take a look at the Recent articles

Cardıac amyloıdosıs

Ravza Yılmaz

Radiology Department, Istanbul Medical Faculty, Istanbul University, Turkey

E-mail : aa

Omer Faruk Unal

Radiology Department, Istanbul Medical Faculty, Istanbul University, Turkey

Zuhal Bayramoglu

Radiology Department, Istanbul Medical Faculty, Istanbul University, Turkey

Ali Aslan Demir

Radiology Department, Istanbul Medical Faculty, Istanbul University, Turkey

Memduh Dursun

Radiology Department, Istanbul Medical Faculty, Istanbul University, Turkey

DOI: 10.15761/GMO.1000102

Article
Article Info
Author Info
Figures & Data

 

We present the case of a 62 year-old male who had clinical signs of congestive heart failure, as angina pectoris, progressive shortness of breath and lower extremity edema. In the echocardiography, there was concentric left ventricular thickening ,biatrial enlargement and increasing echogenicity of the myocardium with normal biventricular dimensions.

He was referred to the department of radiology after these findings and Cardiac MRI (CMRI) was performed to diagnose the cause of restrictive cardiomyopathy .On the short-axis cine images, there were concentric thickening and systolic disfunctions of the left and right ventricules. Delayed-enhanced MRI (DE-MRI) showed circumferential subendocardial enhancement extending into the biatrial and biventricular myocardial wall and also demonstrated pleural effusion (Figure 1A).Also ıt was seen a circumferential subendocardial hypointensity on 3D scar imaging (Figure 1B). Despite aggressive treatment, the patient died. Postmortem analysis demonstrated amyloid cardiac deposition including involvement of the coronary microvasculature. Electron microscopy revealed myocyte compression injury from amyloid infiltration.

The most common cause of restrictive cardiomyopathy is amyloidosis which is caused by extracellular deposition of beta-amyloid protein [1]. Cardiac amyloidosis is a clinical condition including the association of findings on history, physical examination and cardiac imaging. CMRI may be preferred as a diagnostic method in cardiac amyloidosis.

References

1) Vanden Driesen RI, Slaughter RE, Strugnell WE (2006) MR findings in cardiac amyloidosis. AJR Am J Roentgenol 186: 1682-1685.

Editorial Information

Editor-in-Chief

Article Type

Image

Publication history

Received date: June 04, 2017
Accepted date: June 26, 2017
Published date: June 28, 2017

Copyright

©2017 Yılmaz R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Citation

Yılmaz R, Unal OF, Bayramoglu Z, Demir AA, Dursun M (2017) Cardıac amyloıdosıs. Gen Med Open 1: DOI: 10.15761/GMO.1000102

Corresponding author

Zuhal Bayramoglu

Radiology Department,
Istanbul Medical Faculty,
Istanbul University,
Turkey