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Atracurium Besylate: Chemo-degradable and bio-degradable pharmaceutically active drug

Ahmed Ma'mun

Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr-El Aini Street, Cairo, 11562, Egypt

E-mail : aa

Mohamed K Abd El-Rahman

Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr-El Aini Street, Cairo, 11562, Egypt

Mohamed Abd El-Kawy

Pharmaceutical Chemistry Department, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University, 12311, Cairo, Egypt

DOI: 10.15761/GDT.1000152

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In recent years, the whole field of ion-selective electrodes (ISEs) in pharmaceutical sciences has expanded far beyond its original roots. The diverse range of opportunities offered by ISEs was broadly used in a number of pharmaceutical applications, with topics presented ranging from bioanalysis of drugs and metabolites, to protein binding studies, green analytical chemistry, impurity profiling, and drug dissolution in biorelevant media. Inspired from these advances and with the aim of extending the functional capabilities of ISEs, the primary focus of the present paper is the utilization of ISE as a tool in personalized medicine. Given the opportunity to explore biological events in real-time (such as drug metabolism) could be central to personalized medicine. (ATR) is a chemo-degradable and bio-degradable pharmaceutically active drug (Figure 1). Laudanosine (LDS) is the major degradation product and metabolite of ATR and is potentially toxic and reported to possess epileptogenic activity which increases the risk of convulsive effects. In this work, ATR have been subjected to both chemical and biological hydrolysis, and the course of the reactions is monitored by means of an ISE. In this study, we have designed an efficient real-time tracking strategy which substantially resolve the challenges of the ATR chemical and biological degradation kinetics. By utilizing a potentiometric sensor, tracking of ATR chemical and biological degradation kinetics can be performed in a very short time with excellent accuracy.

Figure 1. Pointing to the importance of monitoring the plasma level of ATR and Laudanosine.

Editorial Information

Editor-in-Chief

Yukio Yoneda
Kanazawa University

Article Type

2021 Copyright OAT. All rights reserv

Short Communication

Publication history

Received: July 24, 2018
Accepted: August 06, 2018
Published: August 09, 2018

Copyright

©2018 Ma’mun A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Citation

Ma’mun A, Abd El-Rahman MK, Abd El-Kawy M (2018) Advantages, disadvantages, and specific administration method of acetaminophen. Glob Drugs Therap 3: DOI: 10.15761/GDT.1000152

Corresponding author

Ma'mun A

Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr-El Aini Street, Cairo, 11562, Egypt

Figure 1. Pointing to the importance of monitoring the plasma level of ATR and Laudanosine.