aspirin, colorectal cancer, glycolysis
The previous study has indicated the chemo-protective effect of low-dose aspirin in reducing the incidence of colorectal cancer (CRC) in individuals without cardiovascular disease . However, it is unknown if inhibition of glycolysis in cancer cells by aspirin plays a potential role in this protective effect. Here, we speculate that prophylactic administration of low-dose aspirin decreases the incidence of colorectal cancer upon inhibition of cell glycolysis.
Warburg effect has been consistently observed in and is vital for most types of colorectal cancer, which means cancer cells produce energy by predominant use of glycolysis, irrespective of oxygen availability . Aspirin is a commonly used medication to prevent cardiovascular disease, which has been identified as an inhibitor of glycolysis. Dervisevik et al.  reported that aspirin impaired glycolysis in diabetic rat heart as a result of decreased phosphofructokinase (PFK) activity. In addition, aspirin was suggested to attenuate glycolysis in HCT-116 colon cancer cells by acetylation of glycolytic pathway enzymes . What’s more, aspirin was shown to suppress cancer initiation and progression via promoting cell glycolysis inhibition . All these results undoubtedly have shown that aspirin may have great protective effect against CRC.
- Cea Soriano L, Soriano-Gabarró M, García Rodríguez LA (2017) Incidence of colorectal cancer in new users and non-users of low-dose aspirin without existing cardiovascular disease: A cohort study using The Health Improvement Network. Int J Cardiol 248: 376-381. [Crossref]
- Yeluri S, Madhok B, Prasad KR, Perry SL, Thorpe H, et al. (2010) The mediators of warburg's effect in colorectal cancer: targets for future therapy. Br J Surg 97: 32.
- Dervisevik M, Dinevska-Kovkarovska S, Dimitrovska M, Cipanovska N, Miova B (2014) High dose of aspirin moderates diabetes-induced changes of heart glycogen/glucose metabolism in rats. J Physiol Sci 64: 411-420. [Crossref]
- Marimuthu S1, Chivukula RS, Alfonso LF, Moridani M, Hagen FK, et al. (2011) Aspirin acetylates multiple cellular proteins in HCT-116 colon cancer cells: Identification of novel targets, Int J Oncol 39: 1273-1283. [Crossref]
- Jiang MJ, Dai JJ, Gu DN, Huang Q, Tian L (2016) Aspirin in pancreatic cancer: chemopreventive effects and therapeutic potentials. Biochim Biophys Acta 1866: 163-176. [Crossref]
Letter to Editor
Received: November 10, 2017
Accepted: November 29, 2017
Published: December 04, 2017
©2017 Yuan C. This is an open-access article distributed under the
terms of the Creative Commons Attribution License, which permits unrestricted
use, distribution, and reproduction in any medium, provided the original author
and source are credited.
Yuan C. (2017) Aspirin suppresses colorectal cancer initiation in populations without cardiovascular disease by inhibiting cell glycolysis, Clin Sci Res Rep 1: DOI: 10.15761/CSRR.1000102
Department of Hepatobiliary and Pancreatic Surgery, Zhejiang Provincial People’s Hospital, No. 158 Shangtang Road, Hangzhou 310014, Zhejiang Province, PR China.