Case Report Trends in Medicine and Therapeutics Middle-aged male with purple skin

Disseminated intravascular coagulation (DIC) is a rare complication often associated with other concurrent medical diseases. Once DIC is diagnosed, rapid decline in clinical status can occur, leading to high morbidity and mortality. A well known historic cause of DIC includes severe sepsis secondary to gram-positive bacteria. Due to advances in medical care, more recent cases of fatality attributed to DIC associated with severe sepsis are rare. We present a case of 50-year-old male who experienced a devastating course of purpura fulminans after a progressive decline into septic shock as a result of influenza A pneumonia compounded with streptococcus bacteremia.

A 50-year-old male presented to the emergency department (ED) by ambulance with a one hour history of bluish-purple skin. The patient arrived from home, accompanied by his wife, who stated that two days prior, he complained of a headache, generalized body aches and chills. The patient developed a fever the following morning and spent the day in bed. As per emergency medical services, the patient was hypoxic and required supplemental oxygen in the field. In the ED, the patient's face, chest, and upper extremities appeared purple in color (Figures 1-3); he was tachycardic, hypotensive, and febrile.

Discussion
DIC is often related to an underlying condition that causes a diffuse activation of clotting factors. The overuse of these factors then leads to depletion of such proteins and increased bleeding. Side effects include multiorgan failure and hemorrhage. Common lab findings include: a decreased platelet count on complete blood count (CBC), enlarged  platelets and fragmented red cells, or schistocytes, on peripheral blood smear, a prolonged PT, a prolonged PTT, a markedly elevated D-Dimer, and low fibrinogen level [2]. Treatment is aimed at determining the underlying cause, possible correction of platelets, restoring coagulation factors with fresh frozen plasma, and repletion of fibrinogen with cryoprecipitate to control severe bleeding as warranted [2].
DIC can be associated with sepsis, trauma, cancer, obstetrical complications, vascular disorders, and immunologic disorders.2 Coagulation is characterized by an increase in cytokine release, inflammation, and stimulation of fibrin and thrombotic occlusion of vessels. In patients with sepsis caused by either gram-negative or grampositive organisms, DIC may occur in 30-50% of untreated patients [2,3]. The likely clinical course of the patient pictured in this case was infection with Influenza A pneumonia and secondary streptococcal bacterial infection.
A historical example of non-bacterial infection and concurrent DIC includes the Spanish Flu epidemic in Spain during the 1910s. Similar to this patient, young and healthy individuals experienced a rapid progression of multiorgan failure, experiencing purpura fulminans immediately after being afflicted with influenza [4].

Conclusion
DIC may occur in 30-50% of untreated patients with sepsis caused by gram-positive organisms [2,3]. Treatment of DIC is supportive with identification of the underlying cause. Diffuse hemorrhage and multiorgan failure are severe complications. This patient was admitted to the intensive care unit, treated with intravenous antiviral medication and broad spectrum antibiotics, and unfortunately expired within two weeks of diagnosis. It is imperative to be aware of the rapid progression of DIC, as in the setting of sepsis and diffuse purpura mortality reaches almost 50% without immediate diagnosis and treatment [5].